Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients

LIU Congjin，

LIU Xingdang，

ZHANG Guangming，

LI Ding，

WANG Jian，

YANG Liqin，

JIANG Yuping

Nuclear Science and Techniques

Vol.18, No.4

pp.232-236

Published in print 20 Aug 2007

DOI：10.1016/S1001-8042(07)60052-9

CLC：R445,R445.6

36100

Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that ^99mTc-TRODAT-1 SPECT and ¹³¹I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The ^99mTc-TRODAT-1 image is more accurate and clearer compared with ¹³¹I-FP-CIT.

99mTc-TRODAT-1 SPECT131I-FP-CIT SPECTParkinson's disease

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