Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients

LIU Congjin，

LIU Xingdang，

ZHANG Guangming，

LI Ding，

WANG Jian，

YANG Liqin，

JIANG Yuping

Nuclear Science and Techniques

Vol.18, No.4

pp.232-236

Published in print 20 Aug 2007

DOI：10.1016/S1001-8042(07)60052-9

CLC：R445,R445.6

36000

Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that ^99mTc-TRODAT-1 SPECT and ¹³¹I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The ^99mTc-TRODAT-1 image is more accurate and clearer compared with ¹³¹I-FP-CIT.

99mTc-TRODAT-1 SPECT131I-FP-CIT SPECTParkinson's disease

References

[1]

LIU Xingdang, GUO Liping, JIANG Chengchuan, et al. Shanghai Med J (in Chinese), 2002, 25(10): 607-609.

[2]

LIU Xingdang, LIN Xiangtong, FANG Ping, et al. Chin J Nucl Med (in Chinese), 2000, 20(6): 285-286.

[3]

Hughes A J, Daniel S E, Kilford L, et al. Neurol Neurosurg Psychiatry, 1992, 55: 181-184.

[4]

Eshuis S A, Maquire R P, Leenders K L, et al. Eur J Nucl Med Mol Imaging, 2006, 33(2): 200-209.

[5]

Booij J, Hemelaar J T G M, Speelman J D, et al. J Nucl Med, 1999, 40: 753-761.

[6]

LIU Xingdang, LIN Xiangtong. Chin J Nucl Med (in Chinese), 2003, 23(3): 160-162.

[7]

LIU Xingdang, FANG Ping, CHEN Zhengping, et al. Chin J Nucl Med (in Chinese), 2003, 23(1): 50-51.

[8]

LIU Xingdang, LIN Xiangtong, KUANG Qinfang, et al. Asian J Nucl Med (in Chinese), 2002, 2(3): 180-183.

[9]

LIU Xingdang, LIN Xiangtong. Chin J Nucl Med (in Chinese), 2000, 20(6): 263-265.

[10]

LIU Xingdang, LIN Xiangtong, FANG Ping, et al. Chin J Nucl Med (in Chinese), 2000, 20(3): 140-141.