TALYS code was used to calculate excitation functions for proton induced on ^natAg, ^natCd and ¹¹³In, deuteron induced on ^natAg and alpha induced on ^natPd that lead to produce ¹⁰⁹Cd radioisotope using low and medium energy accelerators; calculates was performed out up to 50 MeV. Recommended thickness of the targets according to SRIM code was premeditated. Theoretical integral yields for any reaction were computed. TALYS 1.0 code predicts that production of a few curries of ¹⁰⁹Cd is feasible using a target of high isotopically enriched ¹¹⁰Cd, proton energy of 15 to 27 MeV, however high cost of the enriched target seems to be not a practical economic alternative to produce ¹⁰⁹Cd. The Ag+p and Ag+d processes can be an efficient route and economic for the production of millicurries of the radioisotope with incident beam energy less 15 MeV using low energy accelerator.