Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast

SYNCHROTRON TECHNOLOGY AND APPLICATIONS

Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast

XIAO Ti-Qiao，

ZHANG Gui-Lin，

XU Hong-Jie，

TIAN Yu-Lian，

HUANG Wan-Xia，

ZHU Pei-Ping

Nuclear Science and Techniques

Vol.14, No.4

pp.217-221

Published in print 01 Nov 2003

CLC：R445.4,O434.1

30403

An experimental study on nondestructive X-ray imaging of inner structure of soft tissues in phase contrast has been conducted with Beijing Synchrotron Radiation Facility (BSRF). Modification to the beamline setup was made to enlarge the X-ray beam section and consequently larger samples could be imaged. In-line setup was employed for experiments. Results on a series of samples were given and soft-tissue details of less than 50μm inside a fresh goldfish were obtained. Diagnosis of tumor in its early stage was also investigated taking SD rats as the model. Tumor at the size of ~100μm was observed. Potential of this technique in clinic diagnosis was discussed.

Nondestructive imagingPhase contrastSynchrotron radiationClinic diagnosis

References

[1]

Fitzgerald R. Physics Today, 2000, 53(7): 23

[2]

Wilkins S W, Gureyev T E, Gao D. Nature, 1996, 384(6607): 335-338

[3]

Arfelli F, Tromba G, Bonvicini V et al.

Elettra Hightlights

, www.elettra.trieste.it, 1997

Baidu Scholar

Google Scholar

[4]

Hwua Y, Tsaia W-L, Hsieha H-H et al. Nucl Instr Methods Phys Res A, 2001, 467-468: 1294-1300

[5]

Stevenson A W, Gureyev T E, Paganin D et al. Nucl Instr Methods Phys Res B, 2003, 199: 427-435

[6]

Snigirev A, Snigireva I, Kohn V et al. Rev Sci Instrum, 1995, 66: 5486-5492

[7]

Max Born, Emil Wolf. Principles of optics (5th ed.), Pergamon Press,1975

[8]

Xiao T Q, Xu H J, Zhang Y J et al. J Mod Opt, 1998, 45(2): 343-353

[9]

Pogany A, Gao D, Wilkins W W. Rev Sci Instrum, 1997, 68(7): 2774-2782

[10]

Snigirev A, Kohn V, Snigireva A et al. Nature, 1996, 384: 49

[11]

Webb S (ed). The Physics of Medical Imaging, Bristol: Hilger, 1978

[12]

Bushuev V A, Ingal V N, Beliaevskaya E A. Crystallography Reports, 1996, 41(5): 766-774

[13]

Beliaevskaya EA, Ingal VN. Il Nuovo Cimento, 1997, 19D(2-4): 553-560

[14]

Ingal V N, Beliaevskaya E A, Brianskaya A P et al. Phys Med Biol, 1998, 43(9): 2555-2567