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Comparative and optimized studies on radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Comparative and optimized studies on radiosynthesis of O-(2-[18F]fluoroethyl)-L-tyrosine

WANG Ming-Wei
YIN Duan-Zhi
WANG Yong-Xian
CHENG Deng-Feng
LI Gu-Cai
ZHOU Wei
Nuclear Science and TechniquesVol.16, No.5pp.283-288Published in print 01 Oct 2005
37100

O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET), one of radiolabelled amino acids, is a very promising brain tumor positron emission tomography (PET) imaging agent and holds clinical potential. This paper described out a comparative and optimized radiosynthesis of [18F]FET, concerning three aspects of its two-step preparation method, including reaction components, heating methods and reaction models. As a result, good radiochemical yield (about 45%, no-decay-corrected) and radiochemical purity (more than 95%) were achieved, and total synthesis time of [18F]FET was shortened within 20 min and radiation exposure time also decreased.

18FL-tyrosineRadiosynthesisPositron emission tomography
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