Acute exposure to high-peak-power pulsed microwaves affecting the histamine H3 receptor expression in rat hippocampus

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Acute exposure to high-peak-power pulsed microwaves affecting the histamine H₃ receptor expression in rat hippocampus

YU Xiao-Dong，

LI Bo，

LI De-Hua，

HE Qi-Yi，

YU Zheng-Ping

Nuclear Science and Techniques

Vol.17, No.4

pp.227-231

Published in print 20 Aug 2006

DOI：10.1016/S1001-8042(06)60042-0

CLC：R122,R122.4

36000

In the Morris Water Maze test, high-peak-power pulsed microwave (MW)-exposed rats displayed some learning and memory behavior dysfunctions, and their escape time and swimming distance to the submerged platform were longer than those of the sham-exposed rats. To understand the molecular mechanism involved, the reverse transcription-polymerase chain reaction (RT-PCR) and the Western-blotting technique were used for investigating the mRNA and protein expression patterns of the histamine H₃ receptor (H₃R) in rat hippocampus. High-peak-power pulsed microwave-exposure did not remarkably lead to the change in expression of H₃R mRNA in rat hippocampi; however, it promoted the up-regulatory expression of the H₃R protein, which was possibly triggered through the mitogen-activated protein kinase (MAPK) pathways. Therefore, further investigation of the molecular mechanism of the MW effects on the learning and memory behaviors is required.

Histamine H3-receptorRat hippocampusMicrowaveExpression

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