Biological reduction and intracellular trapping differences of 188Re(VII) and 99Tcm(VII) in Escherichia coli

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Biological reduction and intracellular trapping differences of ¹⁸⁸Re(VII) and ⁹⁹Tc^m(VII) in Escherichia coli

XU Fenghua，

YIN Duanzhi，

ZHENG Mingqiang，

WANG Yongxian

Nuclear Science and Techniques

Vol.20, No.1

pp.27-30

Published in print 20 Feb 2009

DOI：10.13538/j.1001-8042/nst.20.27-30

30900

⁹⁹Tc^m is the most commonly used diagnostic radioisotope. And ¹⁸⁸Re is an excellent therapeutic radioisotope with a gamma photon for imaging. Both locate in the same group and have very similar properties. ⁹⁹Tc^m(VII) can be partially reduced to a black insoluble precipitate by aerobic cultures of Escherichia coli, and trapped intracellularly. However, ¹⁸⁸Re(VII) cannot be reduced and trapped, because of its lower oxidizing power of perrhenate as compared with pertechnetate or other reasons.

99Tcm188ReEscherichia coliBiological reductionIntracellular trapping

References

[1]

Garcia-garayoa E, schibli R, schubiger P A. Nucl Sci Technol, 2007, 18: 88-100.

[2]

Lloyd J R, Macaskie L E. Appl Environ Microbiol, 1996, 62: 578-582.

[3]

Lloyd J R, Nolting H F, Sole V A, et al. Geomicrobiol, 1998, 15: 43-56.

[4]

Lloyd J R, Cole J A, Macaskie L E. J. Bacteriol, 1997, 179: 2014-2021.

[5]

Lloyd J R, Harding C L, Macaskie L E. Biotechnol Bioeng, 1997, 55: 505-510.

[6]

Rossmann R, Sawers G, Böck A. Mol Microbiol, 1991, 5: 2807-2814.

[7]

Lloyd J R, Thomas G H, Finlay J A. Biotechnol Bioeng, 1999, 66: 122-130.

[8]

Bard A J, Parsons R, Jordan J. Standard Potentials in Aqueous Solution. New York (USA): Marcel Dekker Inc, 1985, 345.

[9]

Shukla S K. J. Chromatogr, 1966, 21: 92-111.

[10]

Breuer M, Schütz A, Engelhardt M, et al. Angiology, 1999, 50: 563-571.

[11]

Pantuck A J, Berger F, Zisman A, et al. J Urol, 2002, 168: 1193-1198.

[12]

Peng F Y, Hills B, Li K.

Intracellular trapping of radionuclides by enzyme-mediated reduction

. US Patent: 2007/0009437 A 1, 2007-01-11.

Baidu Scholar

Google Scholar

[13]

Karine B, Nelli M, Anna P. FEBS Letters, 2002, 516: 172-178.

[14]

http://www.ncbi.nlm.nih.gov/

[15]

Iznaga-Escobar N. Appl Radiat Isot, 2001, 54: 399-406.

[16]

Knapp F F. Cancer Biother & Radiopharm, 1998, 13: 337-341.

[17]

Yin D Z, Yu J F, Wang Y X. Nucl Technol, 2000, 23: 347-352.

[18]

Macaskie L E. CRC Crit. Rev. Biotechnol, 1991, 11: 41-112.

[19]

Lovley D R. Ann Rev Microbiol, 1993, 47: 263-290.