Preparation of β-methyl p-iodophenyl pentadecanoic acid (BMIPP) and 125I-BMIPP

Preparation of β-methyl p-iodophenyl pentadecanoic acid (BMIPP) and ¹²⁵I-BMIPP

WU Chun-Ying，

JI Shu-Ren，

LU Chun-Xiong

Nuclear Science and Techniques

Vol.11, No.4

pp.240-246

Published in print 01 Nov 2000

CLC：R817.9, O621.3+5, O623.61

21100

A method with several steps superior to literature has been developed for the preparation of β-methyl p-iodophenyl pentadecanoic acid(BMIPP). The synthesis and physical properties of BMIPP are described. It is characterized by IR, ¹HNMR, elemental analysis and MS. ¹²⁵I-BMIPP can be prepared by three methods: direct labeling, solid-state transfer labeling and Cu(I) assisted labeling. Cu(I) assisted labeling is simple and not necessary to purify before clinical use. It can fulfil the requirements for kit labeling.

β-methyl p-iodophenyl pentadecanoic acidFatty acid125I-BMIPPRadio labeling yield (RLY)

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