CEREBRAL BLOOD FLOW AND METABOLISM EVALUATION IN COMATOSE PATIENTS BY DYNAMIC SPECT

Alessandro Giordano，

Maria Lucia Calcagni，

Francesco Della Corte，

Mariano Alberto Pennisi，

Guido Galli，

Wang Fengqin，

Zhao Huiyang

Nuclear Science and Techniques

Vol.4, No.1

pp.33-38

Published in print 01 Feb 1993

26900

Thirty patients in coma state underwent dynamic SPECT with ¹³³Xe, a validated technique for the quantitation of CBF by SPECT, using a new brain dedicated tomograph: CERTO-96. CMRO₂ was computed by multiplying the mean CBF by AVDO₂ according to the Fick's principle. The mean values of CBF, AVDO₂ and CMRO₂ in patients with good outcome were significantly different from those with worse outcome. On the basis of the best "discriminant threshold", CBF and AVDO₂ demonstrated an intermediate accuracy in separating the two groups, while CMRO₂ showed a satisfactory accuracy.

Dynamic SPECTCerebral blood flowCerebral metabolic rate of oxygenComatose patients

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