RADIOBROMINE LABELLING OF 3,4-DIHYDROXY-PHENYL-L-ALANINE AND DISTRIBUTION STUDY IN MOUSE BRAIN

Hu Fang，

Li Yongjian

Nuclear Science and Techniques

pp.51-55

Published in print 01 Feb 1993

38700

The synthesis of 3, 4-dihydroxy-6-bromo-phenyl-L-alanine (6-Br-L-dopa), preparation of 3,4-dihydroxy-6-[⁷⁷Br] bromo-phenyl-L-alanine(6-⁷⁷Br-bromo-L-dopa) and its distribution study in mouse brain are described. The radiochemical yield and radiochemical purity of 6-⁷⁷Br-bromo-L-dopa were 8.5% and 93%, respectively. Its distribution in mouse brain after one hour injection indicates that it does pass blood brain barrier. The ratio of uptake in striatum to that in cerebellum was 2.45±0.12. The results appeared that 6-⁷⁷Br-bromo-L-dopa could be used as brain tracer for visualizing dopamine-containing brain structures by using single photon tomography.

6-bromo-L-dopa6-77Br-bromo-L-dopaSPECT-radio-pharmaceuticalDopamine-brain-structure

REFERENCES

[1]

Mazierl Bernard, Loc'h Christian. Appl Radia Isot, 1986, 37: 703.

[2]

Friedman A M, Chevonis J, Zalutsky M et al. J Label Compds Radiopharm, 1979, 16: 66.

[3]

Garnett E S, Firnau G, Nahmias C. Nature, 1983, 305: 137.

[4]

Calne D B, Langston J Willam, Wayhe W R. Nature, 1985, 317: 246.

[5]

Firnan G, Chirakal R, Garnett E S. J Nucl Med, 1984, 25: 1228.

[6]

Wong M, Dejesus O T. J Label Compds Radiopharm, 1987, 24: 1373.