THE EFFECT OF SOME MEDICAL TREATMENTS ON THE RED BLOOD CELLS IN THE PATIENTS WITH THALASSEMIA

Zhang Xiufang，

Shen Linming，

Bao Hongxia，

Ding Xiaolan，

Wang Rongxin，

Liu Yuanyuan，

Gao Naifei，

Huang Youwen

Nuclear Science and Techniques

Vol.3, No.2

pp.73-77

Published in print 01 May 1992

31300

The Mössbauer spectroscopy and circular dichroism measurements have been used to investigate the effect of some medical treatments on the red blood cells (RBCs) of the patients with HbH disease and β -thalassemia major, respectively. The results indicate that both splenectomy and treatment with myleran are effective to alleviate the symptoms of anemia for some patients, but both of them are different in the effect on the RBCs of the patients. On the basis of the results, a hypothesis on the course of denaturation in hemoglobin of the patients is proposed.

β -thalassemia majorMössbauer spectroscopyCircular dichroism HbH

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