Red blood cells (RBC) of the patients with cirrhosis and with primary liver cancer were studied by using Mössbauer spectroscopy. The measurements of RBC from normal adults were made as control. Results showed that the subspectrum representing deoxy-Hb either disappeared or diminished, but no other subspectrum was detected in the samples from the patients. In addition, the immune function of RBC of these two types of patients was measured by using immune-adherence haemagglutination (IAHA), which indicated that its immune function was significantly lower than that of normal adults (P<0.01). These experimental results showed that the components of hemoglobin in RBC are correlated with the immune function of RBC.