LABELLING OF METALLOTHIONEIN WITH <sup>99m</sup>Tc

Bizhong Li; Yonghui Wu; Yuanfang Liu; Jun Li; Yanbing Dong; Chongqing Wang; Binggen Ru; Bin Han; Jiahe Tian

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LABELLING OF METALLOTHIONEIN WITH ^99mTc

Updated：2021-02-05

- LABELLING OF METALLOTHIONEIN WITH ^99mTc
- Nuclear Science and Techniques Vol. 3, Issue 4, (1992)
- Affiliations：
  
  1.Peking University, Beijing 100871, China
  2.General Hospital of P.L. Army, Beijing 100853, China
- Author bio：
  
  To whom all correspondance should be addressed
  
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  Present address is the Institute of Chemistry, Academia Sinica, Beijing 100080
  
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- DOI： CLC：
- Published：01 November 1992，
  
  Received：1991-11，
  
  Revised：1992-04，
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Cite this article
Bizhong Li, Yonghui Wu, Yuanfang Liu, et al. LABELLING OF METALLOTHIONEIN WITH ^99mTc. [J]. Nuclear Science and Techniques 3(4):268-274(1992)
DOI：

Bizhong Li, Yonghui Wu, Yuanfang Liu, et al. LABELLING OF METALLOTHIONEIN WITH ^99mTc. [J]. Nuclear Science and Techniques 3(4):268-274(1992) DOI：

LABELLING OF METALLOTHIONEIN WITH 99m Tc 1 corresp first-author To whom all correspondance should be addressed To whom all correspondance should be addressed 1 1 corresp Present address is the Institute of Chemistry, Academia Sinica, Beijing 100080 Present address is the Institute of Chemistry, Academia Sinica, Beijing 100080 1 1 1 1 2 2 Peking University, Beijing 100871, China Peking University, Beijing 100871, China General Hospital of P.L. Army, Beijing 100853, China General Hospital of P.L. Army, Beijing 100853, China 99m Tc-labelled metallothionein ( 99m Tc-MT) was prepared through both direct and transcomplexation labelling approaches. Buffer systems and a variety of other parameters in the direct labelling procedure were studied in detail. High radiolabelling yields of 93-96% and the specific radioactivity of 3.7 MBg/µg were obtained under optimal conditions by the direct labelling method. The prepared 99m Tc-MT was stable in vitro. The chelate-exchange kinetics of MT with 99m Tc-glucohepatonate and 99m Tc-citrate were also studied. Biodistribution and imaging studies showed that 99m Tc-MT was accumulated in the animal kidneys at an exceptionally high level, indicating that 99m Tc-MT might be a potential renal imaging agent. Metallothionein Technetium-99m Radiolabelling Biodistribution Imaging REFERENCES Morelock M M , Cormier T A , Tolman G L . Inorg Chem , 1988 , 27 : 3137 . Inorg Chem Morelock M M , Tolman G L . Experientia (Basel) , 1987 , Suppl 52 : 247 . Experientia (Basel) Tolman G L . Eur Pat Appl 0137457 , 1984 . Wang C Q , Huang M M , Guo S G et al . Acta Scientiarum Naturalium, Universitatis Pekinensis , 1989 , 25 : 748 . Acta Scientiarum Naturalium, Universitatis Pekinensis Rosebrough S F , Grossman Z D , McAfee J G et al . J Nucl Med , 1988 , 29 : 1212 . J Nucl Med Lin T H , Khentigan A , Winchell H S . J Nucl Med , 1974 , 15 : 34 . J Nucl Med Pan Z Y , Lin J H . Radionuclide Diagnostics (in Chinese) , 1984 , 327 . Radionuclide Diagnostics (in Chinese) Li Bizhong , Wu Yonghui , Li Jun et al . Acta Scientiarum Naturalium , Universitatis Pekinensis , 1992 , in press . Acta Scientiarum Naturalium 1992-11-01 2021-02-05 1992 Nuclear Science and Techniques 4 3

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LABELLING OF METALLOTHIONEIN WITH 99mTc

LABELLING OF METALLOTHIONEIN WITH ^99mTc