Catalytic protection of stannous ion by ascorbic acid in diphosphonic acids solutions

Catalytic protection of stannous ion by ascorbic acid in diphosphonic acids solutions 1 first-author 1 1 1 1 Isotope Department, China Institute of Atomic Energy, Beijing 102413 Isotope Department, China Institute of Atomic Energy, Beijing 102413 The protective ability of ascorbic acid (Vc) on stannous ion and the influence of light irradiation on the stability of stannous ion in diphosphonate medium at pH=5 have been examined in order to attain minimal loss of stannous ion during the production of lyophilized radiopharmaceutical kits. The sum of stannous ion and Vc was determined with iodometric method. It was shown that the protective ability of Vc was still strong at Vc concentration much lower than that of stannous ion and the illumination by fluorescent lamp was unfavorable to the stability of stannous ion. The change of pH in the range 3〜9 did not affect the action of Vc significantly. Stability of stannous ion Bone imaging kits Ascorbic acid Light irradiation References Eckelman W , Richards P . J Nucl Med , 1970 , 11 ( 12 ): 761 J Nucl Med Owunwanne A , Church L B , Blau M . J Nucl Med , 1977 , 18 ( 8 ): 822 J Nucl Med Harding R C , Walton J H . J Phys Chem , 1933 , 37 : 375 J Phys Chem Lachman S J , Tompkins F C . Trans Faraday Soc , 1994 , 40 : 130 Trans Faraday Soc Harding R C , Walton J H . J Phys Chem , 1933 , 37 : 133 J Phys Chem Glodowski S , Kublik Z . Anal Chim Acta , 1981 , 130 ( 1 ): 133 Anal Chim Acta Baker E H . J Appl Chem , 1953 ( 3 ): 323 J Appl Chem Kodina G , Kostim I , Triphonenkova N et al . J Radioanal Nucl Chem, Lett , 1990 , 146 ( 1 ): 57 J Radioanal Nucl Chem, Lett Liang Z , Tan T . Chinese J of Nucl Med (in Chinese) , 1995 , 15 ( 4 ): 262 Chinese J of Nucl Med (in Chinese) Cleynhens B , Bormans G , van Nerom C et al . Nuklearmedizin, Suppl (Stuttgart) , 1991 , 27 : 133 Nuklearmedizin, Suppl (Stuttgart) Rooney M L . Photochem Photobiol , 1983 , 38 ( 5 ): 619 Photochem Photobiol 1997-12-08 1998-05-01 2021-02-05 1998 Nuclear Science and Techniques 2 9