Biodistribution and pharmacokinetics of ^99mTc-CQDO and ^99mTc-CQDO-MeB for new myocardial imaging agent

Biodistribution and pharmacokinetics of 99m Tc-CQDO and 99m Tc-CQDO-MeB for new myocardial imaging agent 1 first-author 1 1 1 1 1 1 1 National Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 National Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 A comparison of 99m Tc- CQDO and 99m Tc-CQDO-MeB has been made for biodistribution and pharmacokinetics. 99m Tc-CQDO and its adducts of methaneboronic acid 99m Tc-CQDO-MeB were prepared by the reduction of Na 99m TcO 4 with SnCl 2 ·2H 2 O in aqueous solution. Radiochemical purity of 99m Tc-CQDO and 99m Tc-CQDO-MeB determined by TLC were over 95% after extraction. Biodistri-butions of 99m Tc-CQDO and 99m Tc-CQDO-MeB in mice demonstrated that both of them could be easily absorbed by myocardium, and the peak uptake of each were 10.83±2.2% ID/g and 11.84±1.69%ID/g, respectively. 99m Tc-CQDO showed rapid clearance from myocardial tissue while 99m Tc-CQDO-MeB had long retention in heart muscle. The myocardial uptake of 99m Tc-CQDO was only 5.88±1.66%ID/g at 10min. and the uptake of 99m Tc-CQDO-MeB was 7.42±0.17%ID/g at 60 min. The elimination of each from blood has a biexponential pattern, the first T 1/2 is 1.38 and 1.5 min, respectively. The partition coefficient of 99m Tc-CQDO and 99m Tc-CQDO-MeB were 20 and 25 at pH 7.40, respectively. Biodistribution Pharmacokinetics 99m Tc-CQDO 99m Tc-CQDO-MeB References Numm A D , Feld T A , Trher E N . Boronic acid adducts of technetium-99m dioxime complexes . U S Patent 4705849 , 1987 Boronic acid adducts of technetium-99m dioxime complexes Milena J , Henzlova , Machac J . J Nucl Med . 1994 , 35 : 575 J Nucl Med Luo S N , Xie M H , Xi Y F et al . Nucl Tech , 1993 , 16 ( 11 ): 687 Nucl Tech Wang F , Yang Y F , Qian Z H et al . Nucl Tech , 1996 , 19 ( 5 ): 265 Nucl Tech 1999-04-02 1999-11-01 2021-02-05 1999 Nuclear Science and Techniques 4 10