Study of proton radiolysis of solid uracil film

Study of proton radiolysis of solid uracil film 1 2 first-author 2 2 2 2 1 1 Department of Technical Physics, Peking University, Beijing 100871 Department of Technical Physics, Peking University, Beijing 100871 Institute of Heavy Ion Physics, Peking University, Beijing 100871 Institute of Heavy Ion Physics, Peking University, Beijing 100871 In order to understand the molecules mechanism of ion irradiation, which has been widely used in many fields such as cancer therapy, uracil, one of the bases of nucleic acid, was chosen in the low energy ion radiolysis research. The solid uracil films with mass thickness of 0.314 mg/cm 2 were irradiated by 200 keV H + ions. The experimental results show that 200 keV H + ions are effective in decomposition of uracil molecules. One of the decomposition products, 5,6-dihydro-uracil, was separated by high performance liquid chromatograph (HPLC) and detected using an UV-light detector. Its yield increases first but then decreases as the ion dose increasing. In addition, the mechanism of uracil decomposition and 5,6-dihydro-uracil formation was also discussed. Low energy proton radiolysis Uracil References Raju R . Int J Radiat Biol . 1995 , 67 : 237 Int J Radiat Biol Folkard M. Prise K M , Vojnovic B et al . Int J Radiat Biol , 1996 , 69 : 729 Int J Radiat Biol Wei Z Q , Xie H M , Han G W et al . Nucl Instr Meth Phys Res , 1995 , B95 : 371 Nucl Instr Meth Phys Res Schaefer A , Huttermann J. Kraft G . Int J Radiat Biol . 1993 , 63 : 139 Int J Radiat Biol Vadim V K , Hitoshi K , Tsuneki I et al . Radiat Phys Chem . 1994 , 44 : 521 Radiat Phys Chem Huang W D. Yu Z L . Acta Biophys Sinica . 1997 , 13 : 250 Acta Biophys Sinica Mason S F , J Chem Soc . 1957 , 4871 J Chem Soc Pruden B , Snipes W , Gordy W , Proc Natl Acad Sci USA , 1965 , 53 : 917 Proc Natl Acad Sci USA Belli M , Cherubini R , Galeazzi G et al . Nucl Instr Meth Phy Res . 1987 , A256 : 576 Nucl Instr Meth Phy Res Supported by NSFC (No.19675004, No. 19890300) 1999-01-08 1999-11-01 2021-02-05 1999 Nuclear Science and Techniques 4 10