Quantum dots enhanced Cerenkov luminescence imaging

Chang-Ran Geng; Yao Ai; Xiao-Bin Tang; Di-Yun Shu; Chun-Hui Gong; Ming-Hua Du; Fa-Quan Ji

doi:10.1007/s41365-019-0599-x

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Quantum dots enhanced Cerenkov luminescence imaging

NUCLEAR CHEMISTRY, RADIOCHEMISTRY, NUCLEAR MEDICINE | Updated：2021-02-01

- Quantum dots enhanced Cerenkov luminescence imaging
- Nuclear Science and Techniques Vol. 30, Issue 5, Article number: 71(2019)
- Affiliations：
  
  1.Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
  2.Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Nanjing 210016, China
  3.Affiliated Hospital of Nanjing University of TCM, Nanjing 210016, China
- Author bio：
  
  Corresponding author, tangxiaobin@nuaa.edu.cn
- Funds：
- DOI：10.1007/s41365-019-0599-x
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Chang-Ran Geng, Yao Ai, Xiao-Bin Tang, et al. Quantum dots enhanced Cerenkov luminescence imaging. [J]. Nuclear Science and Techniques 30(5):71(2019)
DOI：

Chang-Ran Geng, Yao Ai, Xiao-Bin Tang, et al. Quantum dots enhanced Cerenkov luminescence imaging. [J]. Nuclear Science and Techniques 30(5):71(2019) DOI： 10.1007/s41365-019-0599-x.

摘要

Abstract

Cerenkov luminescence imaging (CLI) has been widely investigated for biological imaging. However, the luminescence generated from Cerenkov Effect is relatively weak and has poor penetration ability in biological tissues. These limitations consequently hindered the clinical translation of CLI. In this study, we proposed an in-vitro experimental study for the demonstration of quantum dots (QDs) configurations affected by the improvement of the signal intensity of CLI. Results revealed that the optimal concentrations were 0.1 mg/mL and 0.25 mg/mL for the studied CdSe/ZnS QDs with fluorescence emission peaks of 580 nm and 660 nm, respectively. The detected optical signal intensity with long-wavelength emission QDs were stronger than those with short-wavelength emission QDs. This study illustrates an experiment to study the effects of concentrations and fluorescence emission peaks of QDs on an enhanced optical signal for the external detection of CLI.

关键词

Keywords

Cerenkov luminescence imagingQuantum dotsOptical signalWavelength shift

references

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