In vivo SPECT imaging of an <sup>131</sup>I-labeled PM 2.5 mimic substitute

Dong-Hui Pan; Jie Sheng; Xin-Yu Wang; Qian-Huan Huang; Jun-Jie Yan; Li-Zhen Wang; Run-Ling Yang; Dong-Jian Shi; Yu-Ping Xu; Ming-Qing Chen

doi:10.1007/s41365-020-00818-2

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In vivo SPECT imaging of an ¹³¹I-labeled PM 2.5 mimic substitute

NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-26

- In vivo SPECT imaging of an ¹³¹I-labeled PM 2.5 mimic substitute
- Nuclear Science and Techniques Vol. 31, Issue 11, Article number: 111(2020)
- Affiliations：
  
  1.Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
  2.Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
- Author bio：
  
  xuyuping@jsinm.org
  Correspondence: mqchen@jiangnan.edu.cn;
- Funds：
- DOI：10.1007/s41365-020-00818-2
  CLC：
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Dong-Hui Pan, Jie Sheng, Xin-Yu Wang, et al. In vivo SPECT imaging of an ¹³¹I-labeled PM 2.5 mimic substitute. [J]. Nuclear Science and Techniques 31(11):111(2020)
DOI：

Dong-Hui Pan, Jie Sheng, Xin-Yu Wang, et al. In vivo SPECT imaging of an ¹³¹I-labeled PM 2.5 mimic substitute. [J]. Nuclear Science and Techniques 31(11):111(2020) DOI： 10.1007/s41365-020-00818-2.

摘要

Abstract

The health effects of ambient PM2.5 and its potential mechanisms have generated considerable interest. In vitro cell studies and ex vivo animal experiments may not accurately determine the characteristics of PM2.5 particles. To better understand their detailed mechanisms, we performed an in vivo study using single photon emission tomography (SPECT) imaging. To mimic the PM 2.5 particles, SiO,2, nanoparticles modified by ethylene carbonate or polyvinyl pyrrolidone were labeled with ,131,I. After administration via inhalation, in vivo SPECT imaging of the radiolabeled particles in Sprague Dawley rats was performed. It was found that radioactivity accumulated in the lungs and trachea 6 and 24 h after administration. In addition, significant radioactivity was observed in the abdomen, including the liver and kidneys. The results were also confirmed by ex vivo autoradiography. This study revealed that in vivo SPECT imaging could be an effective method for investigating the properties of PM 2.5 particles.

关键词

Keywords

PM 2.5 mimic substituteEC/SiO2 nanoparticlesSPECT images131I labeling

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Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences

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In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute

DOI：10.1007/s41365-020-00818-2

摘要

Abstract

关键词

Keywords

references

In vivo SPECT imaging of an ¹³¹I-labeled PM 2.5 mimic substitute