BL19U2: Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF

Yi-Wen Li; Guang-Feng Liu; Hong-Jin Wu; Ping Zhou; Chun-Xia Hong; Na Li; Feng-Gang Bian

doi:10.1007/s41365-020-00825-3

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BL19U2: Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF

SYNCHROTRON RADIATION TECHNOLOGY AND APPLICATIONS | Updated：2021-01-26

- BL19U2: Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF
- Nuclear Science and Techniques Vol. 31, Issue 12, Article number: 117(2020)
- Affiliations：
  
  1.Shanghai Advanced Research Institute (Zhangjiang Laboratory), Chinese Academy of Sciences, Shanghai 201204, China
  2.CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
  3.University of Chinese Academy of Sciences, Beijing 100049, China
- Author bio：
  
  lina02@sari.ac.cn
  bianfg@sari.ac.cn
- Funds：
- DOI：10.1007/s41365-020-00825-3
  CLC：
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Yi-Wen Li, Guang-Feng Liu, Hong-Jin Wu, et al. BL19U2: Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF. [J]. Nuclear Science and Techniques 31(12):117(2020)
DOI：

Yi-Wen Li, Guang-Feng Liu, Hong-Jin Wu, et al. BL19U2: Small-angle X-ray scattering beamline for biological macromolecules in solution at SSRF. [J]. Nuclear Science and Techniques 31(12):117(2020) DOI： 10.1007/s41365-020-00825-3.

摘要

Abstract

The BL19U2 at the Shanghai Synchrotron Radiation Facility is a small-angle X-ray scattering beamline dedicated to structural studies pertaining to biological macromolecules in solution. The beamline has been officially opened to users in March 2015, and since then, a series of technological innovations has been developed to optimize beamline performance, thereby significantly improving the data collection efficiency and broadening the application scope of biological small-angle X-ray scattering. BL19U2 is ideal for the high-throughput screening of weakly scattered proteins, protein assemblies, nucleic acids, inorganic nanomaterials, and organic drug molecules. This paper describes the design and overview of the BL19U2 beamline. Versatile sample environments at the experimental station and some recent scientific highlights are presented.

关键词

Keywords

Shanghai Synchrotron Radiation FacilityBiological small-angle X-ray scatteringHigh-throughput screeningBiological macromolecules

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Shanghai Institute of Applied Physics, Chinese Academy of Sciences

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