Preparation and properties of <sup>117m</sup>Sn(Ⅳ)-TTHMP in in-vitro and in small animals

Jiaheng HE; Shunzhong LUO; Shubin JIANG; Yuqing YANG; Guanquan WANG

doi:10.1016/S1001-8042(08)60005-6

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Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-29

- Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals
- Nuclear Science and Techniques Vol. 18, Issue 6, (2007)
- Affiliations：
  
  1.Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, China
- Author bio：
  
  E-mail: msljy@21cn.com
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- DOI：10.1016/S1001-8042(08)60005-6
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Jiaheng HE, Shunzhong LUO, Shubin JIANG, et al. Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals. [J]. Nuclear Science and Techniques 18(6):344-348(2007)
DOI：

Jiaheng HE, Shunzhong LUO, Shubin JIANG, et al. Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals. [J]. Nuclear Science and Techniques 18(6):344-348(2007) DOI： 10.1016/S1001-8042(08)60005-6.

摘要

Abstract

In this work, TTHMP was synthesized and labelled with ,117m, Sn. The preparation conditions, stability and lipophilicity of ,117m,Sn(IV)-TTHMP were investigated. Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the prepararion solution had vital effects on the labeling yield of ,117m,Sn(IV)-TTHMP. It was also found that ,117m,Sn(IV)-TTHMP was hydrophilic and stable at room temperature and 37℃ in open air.,117m,Sn(IV)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals. This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.

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Keywords

117mSnTTHMPBone tumorBiodistribution

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Institute of Nuclear Physics and Chemistry, the Chinese Academy of Engineering Physics

.O. BOX

Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences

Department of Chemistry, University of Zanjan

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Preparation and properties of 117mSn(Ⅳ)-TTHMP in in-vitro and in small animals

DOI：10.1016/S1001-8042(08)60005-6

摘要

Abstract

关键词

Keywords

references

Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals