Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by <sup>12</sup>C<sup>6+</sup> ions

Yang LIU; Hong ZHANG; Luwei ZHANG

doi:10.1016/S1001-8042(08)60016-0

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Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ¹²C⁶⁺ ions

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- Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ¹²C⁶⁺ ions
- Nuclear Science and Techniques Vol. 19, Issue 1, (2008)
- Affiliations：
  
  1.Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
  2.Gansu Agricultural University, Lanzhou 730070, China
- Author bio：
  
  Corresponding author. E-mail address: zhangh@impcas.ac.cn
- Funds：
- DOI：10.1016/S1001-8042(08)60016-0
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Yang LIU, Hong ZHANG, Luwei ZHANG. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ¹²C⁶⁺ ions. [J]. Nuclear Science and Techniques 19(1):17-21(2008)
DOI：

Yang LIU, Hong ZHANG, Luwei ZHANG. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ¹²C⁶⁺ ions. [J]. Nuclear Science and Techniques 19(1):17-21(2008) DOI： 10.1016/S1001-8042(08)60016-0.

摘要

Abstract

The aim of this work is to identify if there is sex specificity on ,12,C,6+, ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females: control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase (4 h), catalase (2 h) and Se-dependent glutathione peroxidase (12 h) have significant changes (,P,<,0.05) between male groups and female groups, suggesting that the lungs of male mice are more sensitive to counteracting the oxidative challenge. Moreover, higher levels of malondiadehyde and lower contents of glutathione were also found in males, indicating that oxidative stress induced by,12,C,6+, ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones.

关键词

Keywords

Sex specificityOxidative stress12C6+ ionMouse lung

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Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by 12C6+ ions

DOI：10.1016/S1001-8042(08)60016-0

摘要

Abstract

关键词

Keywords

references

Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by ¹²C⁶⁺ ions