A high-resolution small animal SPECT system developed at Tsinghua

A high-resolution small animal SPECT system developed at Tsinghua 1 first-author 1 corresp Corresponding author. E-mail address: maty@tsinghua.edu.cn Corresponding author. E-mail address: maty@tsinghua.edu.cn maty@tsinghua.edu.cn 1 1 1 1 1 Key Laboratory of Particle & Radiation Imaging, Ministry of Education; Department of Engineering Physics, Tsinghua University, Beijing 10084, China Key Laboratory of Particle & Radiation Imaging, Ministry of Education; Department of Engineering Physics, Tsinghua University, Beijing 10084, China An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better. This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost. It was developed from a single-head clinical SPECT scanner, with a seven-pinhole collimator and a four-degree-of- freedom motion control stage. Several key techniques were developed, including high-resolution image reconstruction algorithm, high accuracy geometrical calibration method, and optimized system matrix derivation scheme. The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function. Experiments of point source and ultra micro hot rod phantom were conducted. With a spatial resolution of 0.5–0.6 mm, this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system. SPECT Multi-pinhole collimator High resolution System matrix Image reconstruction References Chatziioannou A F . Proc Am Thorac Soc , 2005 , 2 : 533 - 536 . Proc Am Thorac Soc Meikle S R , Kench P , Kassiou M , et al . Phys Med Biol , 2005 , 50 : R45 - R61 . Phys Med Biol Beekman F J , Vastenhouw B . Phys Med Biol , 2004 , 49 : 4579 - 4592 . Phys Med Biol Kastis G A , Barber H B , Barrett H H , et al . IEEE Trans Nucl Sci , 2000 , 47 : 1923 - 1927 . IEEE Trans Nucl Sci Beekman F J , van der Have F , Vastenhouw B , et al . J Nucl Med , 2005 , 46 : 1194 - 1200 . J Nucl Med Schramm N U , Ebel G , Engeland U , et al . IEEE Trans Nucl Sci , 2003 , 50 : 315 - 320 . IEEE Trans Nucl Sci Shao Y , Ma T , Yao R . IEEE Nucl Sci Symp Conf Rec , 2007 , 4285 - 4288 . DiFilippo F P . Phys Med Biol , 2008 , 53 : 4185 - 4201 . Phys Med Biol Dai Q , Qi Y . At Energ Sci Technol , 2009 , 43 : 1034 - 1038 . At Energ Sci Technol Rowe R K , Aarsvold J N , Barrett H H , et al . J Nucl Med , 1993 , 34 : 474 - 480 . J Nucl Med Metzler S D , Bowsher J E , Greer K L , et al . IEEE Trans Med Imag , 2002 , 21 : 878 - 886 . IEEE Trans Med Imag Bal G , Acton P D . Phys Med Biol , 2006 , 51 : 4923 - 4950 . Phys Med Biol Refecas M , Mosler B , Dietz M , et al . IEEE Trans Nucl Sci , 2004 , 51 : 2597 - 2605 . IEEE Trans Nucl Sci Yao R , Ma T , Shao Y . IEEE Trans Nucl Sci , 2009 , 56 : 2651 - 2658 . IEEE Trans Nucl Sci Dai T , Liu Y , Ma T , et al . At Energ Sci Technol , 2011 , 45 : 369 - 373 . At Energ Sci Technol Liu H , Ma T , Dai T , et al . M18-224: High accuracy geometrical calibration for half-mm animal SPECT imaging . IEEE NSS MIC RTSD , Knoxville, Tennessee , Oct, 2010 . M18-224: High accuracy geometrical calibration for half-mm animal SPECT imaging Ma T , Yao R , Shao Y , et al . IEEE Trans Med Imag , 2009 , 28 : 1929 - 1939 . IEEE Trans Med Imag Shepp L A , Vardi Y . IEEE Trans Med Imag , 1982 , MI-1 : 113 - 122 . IEEE Trans Med Imag Hudson H M , Larkin R S . IEEE Trans Med Imag , 1994 , 12 : 601 - 609 . IEEE Trans Med Imag Jan S , Santin G , Strul D , et al . Phys Med Biol , 2004 , 49 : 4543 - 4561 . Phys Med Biol Brun R , Rademakers F . Nucl Inst Meth Phys Res A , 1997 , 389 : 81 - 86 . See also http://root.cern.ch/ . Nucl Inst Meth Phys Res A 10.13538/j.1001-8042/nst.22.344-348 Supported by Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP200800031071) , National Natural Science Foundation of China (No.10975086) , and the National High Technology Research and Development Program of China (No. 2006AA020802) . 2011-04-25 2011-12-20 2021-01-19 2011 Nuclear Science and Techniques 06 22