Investigation of solid-state reaction by terahertz time-domain spectroscopy

Investigation of solid-state reaction by terahertz time-domain spectroscopy 1 first-author 1 corresp Corresponding author. E-mail address: zhaohongwei@sinap.ac.cn Corresponding author. E-mail address: zhaohongwei@sinap.ac.cn zhaohongwei@sinap.ac.cn 1 1 1 Shanghai Institute of Applied physics, Chinese Academy of Sciences, Shanghai 201800, China Shanghai Institute of Applied physics, Chinese Academy of Sciences, Shanghai 201800, China Terahertz time-domain spectroscopy (THz-TDS) was utilized to investigate the solid-state reaction between L(+)-Tartaric acid and sodium hydrogen carbonate. Solid sodium hydrogen L(+)-tartrate monohydrate was synthesized efficiently by mechanical grinding, which is particularly sustainable and environmentally benign. Distinct THz absorptions were observed for pure reactants and the proposed product. The reaction process could be clearly visualized by THz spectral patterns of the reaction mixtures at different grinding time. The observed results were further confirmed by synchrotron radiation X-ray powder diffraction (SRXRPD) and Fourier transform infrared (FT-IR) spectroscopy. The study demonstrates that THz-TDS is an effective novel tool to monitor solid-state reactions in pharmaceutical industry. Terahertz time-domain spectroscopy (THz-TDS) Solid-state reaction Tartaric acid Grinding References Tonouchi M . Nat Photonics , 2007 , 1 : 97 - 105 . Nat Photonics Ueno Y , Ajito K . Anal Sci , 2008 , 24 : 185 - 192 . Anal Sci Walther M , Fischer B , Schall M , et al . Chem Phys Lett , 2000 , 332 : 389 - 395 . Chem Phys Lett Li J . Appl Spectrosc , 2010 , 64 : 231 - 234 . Appl Spectrosc Liu G F , Ma S H , Ji T , et al . Nucl Sci Tech , 2010 , 21 : 209 - 213 . Nucl Sci Tech Strachan C J , Taday P F , Newnham D A , et al . J Pharm Sci , 2005 , 94 : 837 - 846 . J Pharm Sci Kröll J , Darmo J , Unterrainer K . Vib Spectrosc , 2007 , 43 : 324 - 329 . Vib Spectrosc Day G M , Zeitler J A , Jones W , et al . J Phys Chem B , 2006 , 110 : 447 - 456 . J Phys Chem B Liu H B , Chen Y Q , Zhang X C . J Pharm Sci , 2007 , 96 : 927 - 934 . J Pharm Sci Zeitler J A , Newnham D A , Taday P F , et al . J Pharm Sci , 2006 , 95 : 2486 - 2498 . J Pharm Sci Zeitler J A , Kogermann K , Rantanen J , et al . Int J Pharm , 2007 , 334 : 78 - 84 . Int J Pharm Liu H B , Zhang X C . Chem Phys Lett , 2006 , 429 : 229 - 233 . Chem Phys Lett Nguyen K L , Friscic T , Day G M , et al . Nat Mater , 2007 , 6 : 206 - 209 . Nat Mater Parrott E P J , Zeitler J A , Friscic T , et al . Cryst Growth Des , 2009 , 9 : 1452 - 1460 . Cryst Growth Des Limwikrant W , Higashi K , Yamamoto K , et al . Int J Pharm , 2009 , 382 : 50 - 55 . Int J Pharm Nishizawa J I , Tanno T , Oohashi T , et al . Synthetic Met , 2008 , 158 : 278 - 282 . Synthetic Met Ge M , Wang W F , Zhao H W , et al . Chem Phys Lett , 2007 , 444 : 355 - 358 . Chem Phys Lett Shan N , Toda F , Jones W . Chem Commun , 2002 , 38 : 2372 - 2373 . Chem Commun Friscic T , Jones W . Cryst Growth Des , 2009 , 9 : 1621 - 1637 . Cryst Growth Des Abdelkader M M , Elkabbany F , Taha S . J Mater Sci Mater El , 1990 , 1 : 201 - 203 . J Mater Sci Mater El Kaupp G . Crystengcomm , 2006 , 8 : 794 - 804 . Crystengcomm Han J G , Xu H , Zhu Z Y , et al . Chem Phys Lett , 2004 , 392 : 348 - 351 . Chem Phys Lett Zhang Z Y , Yu X H , Zhao H W , et al . Opt Commun , 2007 , 277 : 273 - 276 . Opt Commun Nishikiori R , Yamaguchi M , Takano K , et al . Chem Pharm Bull , 2008 , 56 : 305 - 307 . Chem Pharm Bull Balbuena P B , Blocker W , Dudek R M , et al . J Phys Chem A , 2008 , 112 : 10210 - 10219 . J Phys Chem A Stern F , Beevers C A . Acta Crystallogr , 1950 , 3 : 341 - 346 . Acta Crystallogr Bott R C , Sagatys D S , Lynch D E , et al . Acta Crystallogr C , 1993 , 49 : 1150 - 1152 . Acta Crystallogr C 10.13538/j.1001-8042/nst.22.139-143 Supported by National Natural Science Foundation of China (Nos. 10574134, 10805068, and 60907044) and National Basic Research Program of China (No. 2010CB832903) 2011-03-07 2011-06-20 2021-01-19 2011 Nuclear Science and Techniques 03 22