Scanning transmission proton microscopy tomography of reconstruction cells from simulated data

Conghua ZHANG; Min LI; Qing HOU

doi:10.13538/j.1001-8042/nst.22.89-94

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Scanning transmission proton microscopy tomography of reconstruction cells from simulated data

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- Scanning transmission proton microscopy tomography of reconstruction cells from simulated data
- Scanning transmission proton microscopy tomography of reconstruction cells from simulated data
- 核技术（英文版） 2011年22卷第2期
- 作者机构：
  
  1.Key Laboratory of Radiation Physics and Technology, Ministry of Education, and the Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
  2.Radiation Division, National Institute of Measurement and Testing Technology, Chengdu 610021, China
- 作者简介：
  
  Corresponding author. E-mail address: conghuazhang@sohu.com
  
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- 基金信息：
  
  National Natural Science Foundation of China
- DOI：10.13538/j.1001-8042/nst.22.89-94 中图分类号：
- 纸质出版日期：2011-04-20，
  
  收稿日期：2010-12-05，
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引用本文
Conghua ZHANG, Min LI, Qing HOU. Scanning transmission proton microscopy tomography of reconstruction cells from simulated data[J]. 核技术（英文版）, 2011, 22(2):89-94.

Conghua ZHANG, Min LI, Qing HOU. Scanning transmission proton microscopy tomography of reconstruction cells from simulated data[J]. Nuclear Science and Techniques, 2011, 22(2):89-94.
Conghua ZHANG, Min LI, Qing HOU. Scanning transmission proton microscopy tomography of reconstruction cells from simulated data[J]. 核技术（英文版）, 2011, 22(2):89-94. DOI： 10.13538/j.1001-8042/nst.22.89-94.

Conghua ZHANG, Min LI, Qing HOU. Scanning transmission proton microscopy tomography of reconstruction cells from simulated data[J]. Nuclear Science and Techniques, 2011, 22(2):89-94. DOI： 10.13538/j.1001-8042/nst.22.89-94.

Scanning transmission proton microscopy tomography of reconstruction cells from simulated data 1 2 corresp first-author Corresponding author. E-mail address: conghuazhang@sohu.com Corresponding author. E-mail address: conghuazhang@sohu.com conghuazhang@sohu.com 1 1 Key Laboratory of Radiation Physics and Technology, Ministry of Education, and the Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China Key Laboratory of Radiation Physics and Technology, Ministry of Education, and the Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China Radiation Division, National Institute of Measurement and Testing Technology, Chengdu 610021, China Radiation Division, National Institute of Measurement and Testing Technology, Chengdu 610021, China For scanning transmission proton microscopy tomography, to compare cell images of the proton stopping power and relative electron density, two cell phantoms are designed and simulated by code FLUKA. The cell images are reconstructed by the filtered back projection algorithm, and compared with their tomography imaging. The images of stopping power and relative electron density slightly vary with proton energies, but the internal images are of clear with high resolution. The organic glass image of relative electron density reveals the resolution power of proton tomography. Also, the simulation results reflect effects of the boundary enhancement, the weak artifacts, and the internal structure border extension by multiple scattering. So using proton tomography to analyze internal structure of a cell is a superior. Monte Carlo simulation Proton tomography Cell image Image quality References Ivan E , Margio C L K , Sergei A , et al . Braz J Phys , 2004 , 34 : 804 - 807 . Braz J Phys Ren M , Kan J A van , Bettiol A A , et al . Nucl Instrm Meth B , 2007 , 260 : 124 - 129 . Nucl Instrm Meth B Pontau A E , Antolak A J , Morse D H , et al . Nucl Instrum Meth Phys Res B , 1989 , B40 : 646 - 650 . Nucl Instrum Meth Phys Res B Hanson K M , Bradbury J N , Cannon T M , et al . IEEE Trans Nucl Sci , 1978 , NS-25 : 657 - 660 . IEEE Trans Nucl Sci Frank Watt . Nucl Instrum Meth Phys Res B , 1997 , B130 : 1 - 8 . Nucl Instrum Meth Phys Res B Saint A , Bench G S , Cholewa M , et al . Nucl Instrum Meth Phys Res B , 1991 , B56/57 : 717 - 721 . Nucl Instrum Meth Phys Res B Formenti P , Breese M B H , Connell S H , et al . Nucl Instrum Meth Phys Res B , 1997 , B130 : 230 - 236 . Nucl Instrum Meth Phys Res B Antolak A J , Bench G. S , Pontau A E , et al . Nucl Instrum Meth Phys Res A , 1994 , A353 : 568 - 574 . Nucl Instrum Meth Phys Res A Schwertnera M , Sakellarioub A , Reinerta T , et al . Ultramicroscopy , 2006 , 106 : 574 - 581 . Ultramicroscopy Habchi C , Nguyen D T , Deve G , et al . Nucl Instrum Meth B , 2006 , 249 : 653 - 659 . Nucl Instrum Meth B Beasley D , Spyrou N M . Nucl Instrum Meth B , 2007 , 264 : 323 - 328 . Nucl Instrum Meth B Michelet C , Moretto Ph . Nucl Instrum Meth B , 1999 , 150 : 173 - 178 . Nucl Instrum Meth B Moretto Ph , Llabador Y . Nucl Instrum Meth B , 1997 , 130 : 324 - 334 . Nucl Instrum Meth B Ren M , Kan J A van , Bettiol A A , et al . Nucl Instrum Meth B , 2007 , 260 : 124 - 129 . Nucl Instrum Meth B Dollinger G , Datzmann G , Hauptner A , et al . Nucl Instrum Meth B , 2003 , 210 : 6 - 13 . Nucl Instrum Meth B Li T , Liang J Proc SPIE , 2004 , 5370 : 2067 - 2074 . Liang J Proc SPIE Li T , Liang Z , Mueller K . Nuclear Science Symposium Conference Record, 2003 IEEE , 2003 , 4 : 2767 - 2770 . Nuclear Science Symposium Conference Record, 2003 IEEE Ivan E , Margio C L K , Sergei A. et al . Braz J Phys , 2004 , 34 : 804 - 807 . Braz J Phys Hanson K M , Bradbury J N , Cannon T M , et al . Phys Med Biol , 1981 , 26 : 965 - 983 . Phys Med Biol Zhang C , Hou Q , Gou C , et al . Nucl Sci Tech , 2010 , 21 : 20 - 23 . Nucl Sci Tech Kak A C , Slaney M . Principles of computerized tomographic imaging , http://cobweb.ecn.purdue.edu/~Malcolm/pct/pct-toc.html . Principles of computerized tomographic imaging 10.13538/j.1001-8042/nst.22.89-94 Supported by National Natural Science Foundation (No.10775101) 2010-12-05 2011-04-20 2021-01-19 2011 Nuclear Science and Techniques 02 22

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