Preparation and preliminary biological evaluation of <sup>99m</sup>Tc-ANMdU

Chunxiong LU; Quanfu JIANG; Huixin YU; Songpei WANG; Xiaomin Li; Zhengwu WANG

doi:10.13538/j.1001-8042/nst.21.106-109

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Preparation and preliminary biological evaluation of ^99mTc-ANMdU

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | 更新时间：2021-01-29

- Preparation and preliminary biological evaluation of ^99mTc-ANMdU
- Preparation and preliminary biological evaluation of ^99mTc-ANMdU
- 核技术（英文版） 2010年21卷第2期
- 作者机构：
  
  1.School of Chemical & Material Engineering, Jiangnan University, Wuxi 214122, China
  2.Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
  3.Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
- 作者简介：
  
  Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn
  
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  Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn
  
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- 基金信息：
  
  National Natural Science Foundation of China;Natural Science Foundation of Jiangsu Province;Department of Health of Jiangsu Province
- DOI：10.13538/j.1001-8042/nst.21.106-109 中图分类号：
- 纸质出版日期：2010-04-20，
  
  收稿日期：2009-12-24，
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引用本文
Chunxiong LU, Quanfu JIANG, Huixin YU, 等. Preparation and preliminary biological evaluation of ^99mTc-ANMdU[J]. 核技术（英文版）, 2010, 21(2):106-109.

Chunxiong LU, Quanfu JIANG, Huixin YU, et al. Preparation and preliminary biological evaluation of ^99mTc-ANMdU[J]. Nuclear Science and Techniques, 2010, 21(2):106-109.
Chunxiong LU, Quanfu JIANG, Huixin YU, 等. Preparation and preliminary biological evaluation of ^99mTc-ANMdU[J]. 核技术（英文版）, 2010, 21(2):106-109. DOI： 10.13538/j.1001-8042/nst.21.106-109.

Chunxiong LU, Quanfu JIANG, Huixin YU, et al. Preparation and preliminary biological evaluation of ^99mTc-ANMdU[J]. Nuclear Science and Techniques, 2010, 21(2):106-109. DOI： 10.13538/j.1001-8042/nst.21.106-109.

Preparation and preliminary biological evaluation of 99m Tc-ANMdU 1 2 corresp first-author Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn wangzhengwu@hotmail.com 2 1 2 2 2 1 3 corresp Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn Corresponding author. E-mail address:wangzhengwu@hotmail.com; luchunxiong@yahoo.com.cn wangzhengwu@hotmail.com School of Chemical & Material Engineering, Jiangnan University, Wuxi 214122, China School of Chemical & Material Engineering, Jiangnan University, Wuxi 214122, China Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China Technetium-99m-labeled-5-{2-sulfanylethyl-[2-(2-sulfanylethylamino)acetyl]amino}-methyl-2′-deoxy- uridine ( 99m Tc-ANMdU) was reported. The precursor ANMdU was synthesized by six-step reactions and all intermediates were verified with MS and 1 HNMR. Using SnCl 2 as reducing agent, a labeling reaction was carried out at 100°C for 30 min. The radiochemical purity of the 99m Tc-ANMdU was 96.68%. Partition coefficients were 0.92 and 0.70 at pH 7.0 and 7.4 of the phosphate buffer saline, respectively. Biodistribution of 99m Tc-ANMdU in normal mice showed that the initial uptake of 99m Tc-ANMdU in vivo and the clearance was rapid. Synthesis 99m Tc-ANMdU Biodistribution A thymidine analog References Shields A F , Grierson J R , Dohmen B M , et al . Nat Med , 1998 , 4 ( 11 ): 1334 - 1336 . Nat Med Kubota R , Yamada S , Kubota K , et al . J Nucl Med , 1992 , 33 ( 11 ): 1972 - 1980 . J Nucl Med Lu L , Samuelsson L , Bergstrfm M , et al . J Nucl Med , 2002 , 43 ( 12 ): 1688 - 1698 . J Nucl Med Shields A F , J Nucl Med , 2003 , 44 ( 9 ): 1432 - 1434 . J Nucl Med Barthel H , Perumal M , Latigo J , et al . Eur J Nucl Med Mol Imaging , 2005 , 32 ( 3 ): 257 - 263 . Eur J Nucl Med Mol Imaging Barthel H , Cleij M C , Collingridge, D R , et al . Cancer Res , 2003 , 63 ( 13 ): 3791 - 3798 . Cancer Res Chen W , Cloughesy T , Kamdar N , et al . J Nucl Med , 2005 , 46 ( 6 ): 945 - 952 . J Nucl Med Sun H , Sloan A , Mangner T J , et al . Eur J Nucl Med Mol Imaging , 2005 , 32 ( 1 ): 15 - 22 . Eur J Nucl Med Mol Imaging Zhang Y , Dai X , Kallmes D F , et al . Tetrahedron Lett , 2004 , 45 ( 47 ): 8673 - 8676 . Tetrahedron Lett Teng B , Bai Y , Chang Y , et al . Bioorgan Med Chem Lett , 2007 , 17 ( 12 ): 3440 - 3444 . Bioorgan Med Chem Lett Celen S , Groot T , Balzarini J , et al . Nucl Med Bio , 2007 , 34 ( 3 ): 283 - 291 . Nucl Med Bio Lu C , Wang Z , Jiang Q , et al . J Isoto , 2008 , 21 ( 3 ): 145 - 149 . (in Chinese) J Isoto 10.13538/j.1001-8042/nst.21.106-109 Supported by National Natural Science Foundation of China (20573048 and 20676051) , Natural Science Foundation of Jiangsu Province (BK2008111, BK2008112) and Department of Health of Jiangsu Province (H200624) . 2009-12-24 2010-04-20 2021-01-19 2010 Nuclear Science and Techniques 02 21

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