Comparison of diagnostic accuracy between ¹⁸F-FDG PET and PET/CT for pulmonary neoplasm

Comparison of diagnostic accuracy between 18 F-FDG PET and PET/CT for pulmonary neoplasm 1 first-author 1 corresp Corresponding author. E-mail address:fudanzhsh@hotmail.com Corresponding author. E-mail address:fudanzhsh@hotmail.com fudanzhsh@hotmail.com 2 1 1 1 3 Department of PET/CT Center, No.1 Hospital Affiliated to Guangzhou Medical College, Guangzhou 510230, China Department of PET/CT Center, No.1 Hospital Affiliated to Guangzhou Medical College, Guangzhou 510230, China Department of Nuclear Medicine, The Chinese PLA General Hospital, Beijing 100853, China Department of Nuclear Medicine, The Chinese PLA General Hospital, Beijing 100853, China Department of Nuclear Medicine, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China Department of Nuclear Medicine, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China Aimed at comparing diagnostic accuracy of 18 F-FDG PET with PET/CT for pulmonary neoplasm, a study based on multi-center clinical trial of the diagnoses, in randomized and semi-blind ways, was executed from January 2006 to June 2007. It included 55 patients, i.e. 16 with histopathologically proved lung tumors, 16 with tuberculosis and 23 with benign lesions (inflammation, pseudotumor, granuloma, fibrosis and others). The histopathologic and clinic results were served as reference standard. Statistical significances in pulmonary nodule diagnosis between 18 F-FDG PET and PET/CT were determined with 95% confidence interval obtained by ROC analysis. The 18 F-FDG PET detected lung neoplasm with a sensitivity of 87.5% (14/16), a specificity of 59.0% (23/39), an accuracy of 67.3% (37/55) and a positive-likelihood ratio of 2.13. The 18 F-FDG PET/CT detected lung neoplasm with a sensitivity of 93.8% (15/16), a specificity of 61.5% (24/39), an accuracy of 70.9% (39/55) and a positive-likelihood ratio of 2.43. The area under curves (AUC) of 18 F-FDG PET and PET/CT were 0.803±0.068 and 0.799±0.063, respectively. It can be concluded that the diagnostic accuracy for malignant pulmonary nodules between 18 F-FDG PET and PET/CT was not statistically different. 18 F-FDG PET/CT Pulmonary neoplasm Receiver operating characteristic References Ding Q Y , Hua Y Q , Guan Y H , et al . Chin Nucl Med , 2005 , 25 : 261 - 263 (in Chinese) . Chin Nucl Med Kim S K , Allen-Auerbach M , Goldin J , et al . J Nucl Med , 2007 , 48 : 214 - 220 . J Nucl Med Tian J H , Yang X F , Yu L J , et al . J Nucl Med , 2008 , 49 : 186 - 194 . J Nucl Med Pan Z H Y . Clinical nuclear medicine . Beijing : Atomic Energy Press , 1994 , 109 - 118 (in Chinese) . Clinical nuclear medicine NCCN clinical practice guideline in oncology: non-small cell lung cancer . Fort Washington : National Comprehensive Cancer Network , 2007 (in Chinese) . http://www.nccn-china.org/images/PDF/NSCLC%202007%20Guideline%20Chinese%20Edition%20%20(DRAFT-2)%20NCCN-APPROVED%2007-17-07.pdf . NCCN clinical practice guideline in oncology: non-small cell lung cancer National economic and social development of statistical bulletin . Beijing : National Bureau of Statistics of China , 2008 (in Chinese) . http://www.stats.gov.cn/tjgb/ndtjgb/qgndtjgb/t20080228_402464933.htm.2008.2.28 . National economic and social development of statistical bulletin The U.S. population clock . Washington : U.S. Census Bureau, Population Division , 2008 . http://www.census.gov/population/www/popclockus.html . The estimated TB incidence in China versus America . World Health Organization, Global Tuberculosis Database , 2008 . http://www.who.int/globalatlas/dataQuery/reportData.asp?rptType=1.2008.3.17 . The estimated TB incidence in China versus America Chen P , Tian J H , Yang X F , et al . Chin Nucl Med , 2008 , 28 : 151 - 153 (in Chinese) . Chin Nucl Med 10.13538/j.1001-8042/nst.20.17-21 Supported by Health Bureau of Guangzhou City (Grant No.2007-YB-159) 2008-09-02 2009-02-20 2021-01-19 2009 Nuclear Science and Techniques 01 20