In-line X-ray phase-contrast imaging of murine liver microvasculature <italic style="font-style: italic">ex vivo</italic>

Beilei LI; Min XU; Weizhong WU; Guanyun PENG; Xi ZHANG; Yifeng PENG; Hongcheng SHI; Shaoliang CHEN

doi:10.13538/j.1001-8042/nst.23.10-14

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In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo

SYNCHROTRON TECHNOLOGY AND APPLICATIONS | 更新时间：2021-01-29

- In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo
- In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo
- 核技术（英文版） 2012年23卷第1期
- 作者机构：
  
  1.Department of Nuclear Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
  2.Liver Cancer Institute, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
  3.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
  4.Department of Radiology, Tumor Hospital Affiliated to Fudan University, Shanghai 200032, China
  5.Department of Radiology, No. 10 People's Hospital Affiliated to Tongji University, Shanghai 200072, China
- 作者简介：
  
  Corresponding author. E-mail address: chen.shaoliang@zs-hospital.sh.cn
  
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- 基金信息：
  
  National Basic Research Program of China
- DOI：10.13538/j.1001-8042/nst.23.10-14 中图分类号：
- 纸质出版日期：2012-02-20，
  
  收稿日期：2011-06-27，
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引用本文
Beilei LI, Min XU, Weizhong WU, 等. In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo[J]. 核技术（英文版）, 2012, 23(1):10-14.

Beilei LI, Min XU, Weizhong WU, et al. In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo[J]. Nuclear Science and Techniques, 2012, 23(1):10-14.
Beilei LI, Min XU, Weizhong WU, 等. In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo[J]. 核技术（英文版）, 2012, 23(1):10-14. DOI： 10.13538/j.1001-8042/nst.23.10-14.

Beilei LI, Min XU, Weizhong WU, et al. In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo[J]. Nuclear Science and Techniques, 2012, 23(1):10-14. DOI： 10.13538/j.1001-8042/nst.23.10-14.

In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo 1 first-author 1 2 3 4 5 1 1 corresp Corresponding author. E-mail address: chen.shaoliang@zs-hospital.sh.cn Corresponding author. E-mail address: chen.shaoliang@zs-hospital.sh.cn chen.shaoliang@zs-hospital.sh.cn Department of Nuclear Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China Department of Nuclear Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China Liver Cancer Institute, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China Liver Cancer Institute, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Department of Radiology, Tumor Hospital Affiliated to Fudan University, Shanghai 200032, China Department of Radiology, Tumor Hospital Affiliated to Fudan University, Shanghai 200032, China Department of Radiology, No. 10 People's Hospital Affiliated to Tongji University, Shanghai 200072, China Department of Radiology, No. 10 People's Hospital Affiliated to Tongji University, Shanghai 200072, China Imaging blood vessels is of importance for determining the vascular distribution of organs and tumors. Phase-contrast X-ray imaging can reveal the vessels in much more detail than conventional X-ray absorption method. Visualizing murine liver microvasculature ex vivo with phase-contrast X-ray imaging was performed at Shanghai Synchrotron Radiation Facility. Barium sulfate and physiological saline were used as contrast agents for the blood vessels. Blood vessels of < Φ 20 μm could be detected by replacing resident blood with physiological saline or barium sulfate. An entire branch of the portal vein (from the main axial portal vein to the ninth generation of branching) could be captured in a single phase-contrast image. It is demonstrated that selective angiography based on phase contrast X-ray imaging, with a physiological material of low Z elements (such as saline) being the contrast agent, is a viable imaging strategy. Further efforts will be focused on using the technique to image tumor angiogenesis. Synchrotron radiation X-ray Phase-contrast imaging Microvascular Liver References Chen J G , Zhang S W . Semin Cancer Biol , 2011 , 21 : 59 - 69 . Semin Cancer Biol Eichhorn M E , Kleespies A , Angele M K , et al . Langenbecks Arch Surg , 2007 , 392 : 371 - 379 . Langenbecks Arch Surg Chen J A , Shi M , Li J Q , et al . Hepatol Int , 2010 , 4 : 537 - 547 . Hepatol Int Mori H , Hyodo K , Tobita K , Chujo M , et al . Circulation , 1994 , 89 : 863 - 871 . Circulation Gao D , Pogany A , Stevenson A W , et al . Radiographics , 1998 , 18 : 1257 - 1267 . Radiographics Zhou S A , Brahme A . Phys Med , 2008 , 24 : 129 - 148 . Phys Med Momose A , Takeda T , Itai Y . Radiology , 2000 , 217 : 593 - 596 . Radiology Takeda T , Momose A , Wu J , et al . Circulation , 2002 , 105 : 1708 - 1712 . Circulation Zhang L , Hu C , Zhao T , et al . Eur J Radiol, EURR-4925(2010)005 . Eur J Radiol, EURR-4925(2010)005 Zhang X , Liu X S , Yang X R , et al . Phy Med Biol , 2008 , 53 : 535 - 543 . Phy Med Biol Kobayashi S , Hori M , Dono K , et al . J Hepatol , 2004 , 40 : 405 - 408 . J Hepatol Liu P , Sun J , Zhao J , et al . J Synchrotron Radiat , 2010 , 17 : 517 - 521 . J Synchrotron Radiat Lu W , Dong Z , Liu Z , et al . J Surg Res , 2010 , 164 : e193 - 139 . J Surg Res Momose A , Takeda T , Itai Y . Acad Radiol , 1995 , 2 : 883 - 887 . Acad Radiol Plouraboue F , Cloetens P , Fonta C , et al . J Microsc , 2004 , 215 : 139 - 148 . J Microsc Risser L , Plouraboué F , Steyer A , et al . J Cereb Blood Flow Metab , 2007 , 27 : 293 - 303 . J Cereb Blood Flow Metab Yamashita T . Invest Radiol , 2001 , 36 : 713 - 720 . Invest Radiol Givvimani S , Sen U , Tyagi N , et al . Arch.Physiol Biochem , 2011 , 117 : 1 - 7 . Arch.Physiol Biochem Xiao T Q , Bergamaschi A , Dreossi D , et al . Nucl Instru Meth.A , 2005 , 548 : 155 - 162 . Nucl Instru Meth.A 10.13538/j.1001-8042/nst.23.10-14 Supported by National Basic Research Program of China (973 Program Grant No. 2010CB834305) . 2011-06-27 2012-02-20 2021-01-19 2012 Nuclear Science and Techniques 01 23

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