Complement of <sup>99m</sup>Tc-octreotide scintimammography to mammography in evaluating breast cancers

Xinhui SU; Xiaojiang HE; Hua WU; Weiming PAN; Jingxiong HUANG; Hao YU; Guibing CHEN; Wei WANG

doi:10.13538/j.1001-8042/nst.21.24-28

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Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | 更新时间：2021-01-29

- Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers
- Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers
- 核技术（英文版） 2010年21卷第1期
- 作者机构：
  
  1.Department of Nuclear Medicine, No.1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 361003, China.
  2.Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China.
- 作者简介：
  
  Corresponding author. E-mail address:wangwei0976@163. com
  
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- 基金信息：
  
  Xiamen Municipal Health Bureau
- DOI：10.13538/j.1001-8042/nst.21.24-28 中图分类号：
- 纸质出版日期：2010-02-20，
  
  收稿日期：2009-08-31，
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引用本文
Xinhui SU, Xiaojiang HE, Hua WU, 等. Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers[J]. 核技术（英文版）, 2010, 21(1):24-28.

Xinhui SU, Xiaojiang HE, Hua WU, et al. Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers[J]. Nuclear Science and Techniques, 2010, 21(1):24-28.
Xinhui SU, Xiaojiang HE, Hua WU, 等. Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers[J]. 核技术（英文版）, 2010, 21(1):24-28. DOI： 10.13538/j.1001-8042/nst.21.24-28.

Xinhui SU, Xiaojiang HE, Hua WU, et al. Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers[J]. Nuclear Science and Techniques, 2010, 21(1):24-28. DOI： 10.13538/j.1001-8042/nst.21.24-28.

Complement of 99m Tc-octreotide scintimammography to mammography in evaluating breast cancers 1 first-author 1 1 1 1 1 1 2 corresp Corresponding author. E-mail address:wangwei0976@163. com Corresponding author. E-mail address:wangwei0976@163. com wangwei0976@163. com Department of Nuclear Medicine, No.1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 361003, China. Department of Nuclear Medicine, No.1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 361003, China. Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China. Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China. In this paper, the 99m Tc-octreotide scintimammography as a useful complementary technique of mammography was evaluated in diagnosing breast cancers. The 45 breast lesions were consecutively detected by mammography, and 99m Tc-octreotide scintimammography, and both combination technique on the basis of self-examination, physical examination. Clinical diagnosis was confirmed by histopathologic analysis. Radioactivity uptake ratios for tumor vs normal breast tissues (T/NT) were calculated using regions of interest. In the breast cancer groups and the benign lesion groups, the average uptake ratios of the 99m Tc-octreotide were 1.63±0.19 and 1.09±0.13, respectively, and t was 9.638 ( P < 0.001). Based on sensitivity, specificity, accuracy, positive predicting value, and negative predicting value, 99m Tc-octreotide scintimammography was 87%, 79%, 84%, 90%, and 73%, the mammography was 65%, 64%, 64%, 80%, and 45%, and both combination was 95%, 100%, 97%, 100% and 92%, respectively. This showed that the 99m Tc-octreotide scintimammography was more useful than mammography in the evaluating suspected breast cancers, and the combination technique can accurately discriminate lesions. Breast cancer diagnosis 99m Tc-octreotide scintimammograpy Mammography References Yang L , Li L D , Chen Y D , et al . Parkin. Chin J Oncol , 2006 , 28 ( 6 ): 438 - 440 . Parkin. Chin J Oncol Mulero F , Nicolás F , Castellón M I , et al . Rev Esp Med Nucl , 2000 , 19 ( 5 ): 344 - 349 . Rev Esp Med Nucl Berg W A , Gutierrez L , NessAiver M S , et al . Radiology , 2004 , 233 ( 3 ): 830 - 849 . Radiology Prats E , Aisa F , Abós M D , et al . J Nucl Med , 1999 , 40 ( 2 ): 296 - 301 . J Nucl Med Brazeau P , Vale W , Burgus R , et al . Science , 1973 , 179 ( 68 ): 77 - 79 . Science Epelbaum J . Prog Neurobiol , 1986 , 27 ( 1 ): 63 - 100 . Prog Neurobiol Arimura A , Fishback JB . Neuroendocrinol , 1981 , 33 ( 4 ): 246 - 256 . Neuroendocrinol Patel Y C , Reichlin S . Endocrinol , 1978 , 102 ( 2 ): 523 - 530 . Endocrinol Reichlin S J , Lab Clin Med , 1987 , 109 ( 3 ): 320 - 326 . Lab Clin Med Khanna G , Bushnell D , O'Dorisio M S . Oncologist . 2008 , 13 ( 4 ): 382 - 389 . Oncologist Patel Y C . Front Neuroendocrinol , 1999 , 20 ( 3 ): 157 - 198 . Front Neuroendocrinol Reubi J C , Horisberger U , Kappeler A , et al . Blood , 1998 , 92 ( 1 ): 191 - 197 . Blood Reubi J C , Waser B , Schaer J C , et al . Eur J Nucl Med , 2001 , 28 ( 7 ): 836 - 846 . Eur J Nucl Med Pinzani P , Orlando C , Raggi CC , et al . Regul Pept , 2001 , 99 ( 2-3 ): 79 - 86 . Regul Pept Wang F , Wang Z , Wu J , et al . Nucl Med Biol , 2008 , 35 ( 6 ): 665 - 671 . Nucl Med Biol Schulz S , Helmholz T , Schmitt J , et al . Breast Cancer Res Treat , 2002 , 72 ( 3 ): 221 - 226 . Breast Cancer Res Treat Schaer J C , Waser B , Mengod G , et al . Int J Cancer , 1997 , 70 : 530 - 537 . Int J Cancer Öhrvall U , Westlin J E , Nilsson S , et al . Cancer Res , 1995 , 55 ( 23 ): 5794 - 5800 . Cancer Res Zhang X M , Feng J , Ma H L , et al . Chin J Imaging Technol , 2006 , 22 ( 6 ): 945 - 948 . Chin J Imaging Technol Zhang J S , Deng N V , Li S , et al . Chin J Nucl Med , 2004 , 24 ( 1 ): 24 - 26 . Chin J Nucl Med 10.13538/j.1001-8042/nst.21.24-28 Supported by Xiamen Municipal Health Bureau (Grant No. WSK0614) . 2009-08-31 2010-02-20 2021-01-19 2010 Nuclear Science and Techniques 01 21

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Complement of 99mTc-octreotide scintimammography to mammography in evaluating breast cancers

Complement of ^99mTc-octreotide scintimammography to mammography in evaluating breast cancers