Biodistribution study of [<sup>61</sup>Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

Amir Reza JALILIAN; Saeed SHANESAZZADEH; Pejaman ROWSHANFARZAD; Fatemeh BOLOURINOVIN; Abbas MAJDABADI

doi:10.1016/S1001-8042(08)60043-3

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Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | 更新时间：2021-01-29

- Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer
- Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer
- 核技术（英文版） 2008年19卷第3期
- 作者机构：
  
  1.Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran;
  2.Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
- 作者简介：
  
  Corresponding author. E-mail: ajalilian@nrcam.org
  
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- 基金信息：
- DOI：10.1016/S1001-8042(08)60043-3 中图分类号： R817.4,O621.3⁺5
- 纸质出版日期：2008-06-20，
  
  收稿日期：2008-01-24，
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引用本文
Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, 等. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer[J]. 核技术（英文版）, 2008, 19(3):159-164.

Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, et al. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer[J]. Nuclear Science and Techniques, 2008, 19(3):159-164.
Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, 等. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer[J]. 核技术（英文版）, 2008, 19(3):159-164. DOI： 10.1016/S1001-8042(08)60043-3.

Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, et al. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer[J]. Nuclear Science and Techniques, 2008, 19(3):159-164. DOI： 10.1016/S1001-8042(08)60043-3.

Biodistribution study of [ 61 Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer 1 corresp first-author Corresponding author. E-mail: ajalilian@nrcam.org Corresponding author. E-mail: ajalilian@nrcam.org ajalilian@nrcam.org 2 1 1 1 Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran; Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran; Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran [ 61 Cu]-labeled pyruvaldehyde-bis(N-4-methylthiosemicarbazone) ( 61 Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the nat Zn(p,x) 61 Cu nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150 μA irradiation for 76 min, about 6.006 Ci of 61 Cu 2+ was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. 61 Cu-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [ 61 Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors. Copper-61 PTSM Biodistribution Radiolabeling References Jalilian AR , Seyfi P , Afarideh H , et al . Int. J Appl Radiat Isot . 2000 , 5 : 545 - 555 . Int. J Appl Radiat Isot Jalilian AR , Afarideh H , Shafiee A , et al . J Pharm Pharmaceut. Sci . 2000 ; 23 : 114 - 124 . J Pharm Pharmaceut. Sci Jalilian AR , Afarideh H , Shafiee A , et al . J Labelled Compd Radiopharm . 2001 , 44 : 11 - 21 . J Labelled Compd Radiopharm Tolmachev V , Lundqvist H , Einarsson L . Int J Appl Radiat Isot . 1998 , 49 : 79 - 81 . Int J Appl Radiat Isot McCarthy DW , Bass LA , Cutler PD , et al . Nucl Med Biol . 1999 , 26 : 351 - 358 . Nucl Med Biol Ma DF , Lu T , et al . Nucl Med Biol . 2002 ; 29 : 91 - 105 Nucl Med Biol Fukumura T , Okada K , Szelecsényi F , et al . Radiochimica Acta . 2004 , 92 : 209 - 214 . Radiochimica Acta Lewis JS , Sharp TL , Laforest R , et al . J Nucl Med . 2001 , 42 : 655 - 661 . J Nucl Med Rowshanfarzad P , Sabet M , Jalilian AR , et al . Applied Radiation and Isotopes , 2006 , 64 : 1563 - 1573 . Applied Radiation and Isotopes Jalilian AR , Sabet M , Rowshanfarzad P , et al . Journal of Radioanalytical and Nuclear Chemistry , 2006 , 269 : 147 - 154 . Journal of Radioanalytical and Nuclear Chemistry Jalilian AR , Rowshanfarzad P , Sabet M . Nukleonika , 2006 , 51 : 111 - 117 . Nukleonika Jalilian AR , Rowshanfarzad P , Sabet M , et al . Applied Radiation and Isotopes , 2006 , 64 : 337 - 341 . Applied Radiation and Isotopes Green MA . Nucl Med Biol 1987 , 14 : 59 - 61 . Nucl Med Biol Marczenko Z . Spectrophotometric determination of elements , 4 th Ed. Warsaw : Ellis Horwood Ltd ., 1976 : 601 - 603 . Spectrophotometric determination of elements Kostyniak PJ , Nakeeb SM , Schopp EM , et al . J Appl Toxicol , 1990 , 10 : 417 - 421 . J Appl Toxicol Shelton ME , Green MA , Mathias CJ , et al . Circulation , 1990 , 82 : 990 - 997 . Circulation Young H , Carnochan P , Zweit J , et al . Eur J Nucl Med , 1994 , 21 : 336 - 341 . Eur J Nucl Med Young H , Carnochan P , Zweit J , et al . J Nucl Biol Med , 1994 , 38 : 89 - 91 . J Nucl Biol Med Wada K , Fujibayashi Y , Taniuchi H , et al . Nucl Med Biol , 1994 , 21 : 613 - 617 . Nucl Med Biol Jason SL , Laforest R , Buettner TL , et al . Proc Natl Acad Sci USA , 2001 , 98 : 1206 - 1211 . Proc Natl Acad Sci USA Blann M , Bislinghoff J , Code Alice/Livermore 91, Lawrence Livermore National Laboratory, Internal Report, UCID-19614 ( 1991 ). Code Alice/Livermore 91, Lawrence Livermore National Laboratory, Internal Report, UCID-19614 Ziegler JF , Biersack JP , Littmark U . The stopping and range of ions in matter (SRIM Code). Version 2000 XX , 2000 . The stopping and range of ions in matter (SRIM Code). Version 2000 XX Weisberg A M , Gold plating , 9 th Ed., ASM International , U.S.A , 1990 : 247 . Gold plating Hilgers K , Stoll T , Skakun Y , et al . Appl Radiat Isot , 2003 , 59 : 343 - 351 . Appl Radiat Isot Boothe TE , Tavano E , Munoz J , et al . J Label Comp Radiopharm , 1991 , 30 : 108 . J Label Comp Radiopharm Gingras BA , Suprunchuk T , Bayley CH . Can J Chem , 1962 , 40 : 1053 - 1057 . Can J Chem Marczenko Z . Spectrophotometric determination of elements , 4 th Ed., Chichester : Ellis Horwood Ltd ., 1976 : 369 . Spectrophotometric determination of elements Wallhaus TR , Lacy J , Whang J , et al . J Nucl Med , 1998 , 39 : 1958 - 1964 . J Nucl Med 10.1016/S1001-8042(08)60043-3 R817.4,O621.3 + 5 2008-01-24 2008-06-20 2021-01-19 2008 Nuclear Science and Techniques 03 19

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Biodistribution study of [61Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer