Evaluation of suspected local recurrence in lung cancer and head & neck cancer: A comparison between ^99mTc-HL91 SPECT and CT for biopsy proven lesions

Evaluation of suspected local recurrence in lung cancer and head & neck cancer: A comparison between 99m Tc-HL91 SPECT and CT for biopsy proven lesions 1 first-author 1 1 1 1 1 1 2 1 corresp Corresponding author. E-mail address: wuhua1025@163.com Corresponding author. E-mail address: wuhua1025@163.com wuhua1025@163.com Department of Nuclear Medicine, No.1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 316003, China Department of Nuclear Medicine, No.1 Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 316003, China School of Life Sciences, Xiamen University, Xiamen 316003, China School of Life Sciences, Xiamen University, Xiamen 316003, China CT has rather low accuracy for the follow-up of tumors after therapy. This study was to determine whether the diagnostic accuracy can be improved with 99m Tc-HL91 SPECT in comparison with parallel results of CT imaging. Thirty patients of lung cancer or head & neck cancer, suspected of recurrences on clinical symptoms and CT during clinical follow-up after therapy, underwent 99m Tc-HL91 SPECT. The radioactivity ratios of tumor to normal tissues (T/NT) were calculated using the region of interest technique. Results of 99m Tc-HL91 SPECT were verified by histopathology. The 99m Tc-HL91 average uptake ratios of T/NT in the group of recurrent lesions and non-recurrent lesions were 1.58±0.16 and 1.18±0.14, respectively. A significant difference was found between T/NT data of the two phases ( t =4.87, P < 0.001).The 99m Tc-HL91 SPECT shows sensitivity of 72.73%, specificity of 89.47% and accuracy of 83.83% for differentiating recurrent lesion, while the CT shows sensitivity of 63.63%, specificity of 84.21% and accuracy of 76.67%. A combination of 99m Tc-HL91 SPECT and CT for 21 patients with lung cancers or head & neck cancers with congruent results shows sensitivity of 100%, specificity of 94.12% and accuracy of 95.23%. It is concluded that 99m Tc-HL91 SPECT may play a role in differentiating recurrent lesions in patients with lung cancer and head & neck cancer. Furthermore, the combination of CT and 99m Tc-HL91 SPECT is a more effective method for diagnosing recurrence of lung cancer and head & neck cancer. Tumor recurrence SPECT 99m Tc-HL91 CT References Som P M , Biller H F . Radiology , 1983 , 148 : 157 - 160 . Radiology Di Santis D J , Balfe D M , Hayden R E , et al . Radiology , 1984 , 153 : 713 - 717 . Radiology Galenby R A , Coia L R , Richter M P , et al . Radiology , 1985 , 156 : 211 - 214 . Radiology Höckel M , Schlenger K , Knoop C , et al . Cancer Res , 1991 , 51 : 6098 - 6102 . Cancer Res Cherif A , Wallace S , Yang D J , et al . J Drug Target , 1996 , 4 : 31 - 39 . J Drug Target Gatenby R A , Kessler H B , Rosenblum J S , et al . Int J Radial Oncol Biol Phys , 1988 , 14 : 831 - 838 . Int J Radial Oncol Biol Phys Höckel M , Knoop C , Schlenger K , et al . Adv Exp Med Biol , 1994 , 345 : 445 - 450 . Adv Exp Med Biol Brizel D M , Scully S P , Harrelson J M , et al . Cancer Res , 1996 , 56 : 941 - 943 . Cancer Res Graeber T G , Osmanian C , Jacks T , et al . Nature , 1996 , 379 : 88 - 91 . Nature Rasey J S , Koh W J , Grierson J R , et al . Int J Radial Oncol Biol Phys , 1989 , 17 : 985 - 991 . Int J Radial Oncol Biol Phys Mannan R H , Somayaji V V , Lee J , et al . J Nucl Med , 1991 , 32 : 1764 - 1770 . J Nucl Med Zhang X , Melo T , Ballinger J R , et al . Int J Radiat Oncol Biol Phys , 1998 , 42 : 737 - 740 . Int J Radiat Oncol Biol Phys Cook G J R , Houston S , Barrington S F , et al . J Nucl Med , 1998 , 39 : 99 - 103 . J Nucl Med Yutani k , Kusuoka H , Fukuchi K , et al . J Nucl Med , 1999 , 40 : 854 - 861 . J Nucl Med YAO Zhiming , QU Wangying , ZHOU Ying , et al . Chin Med J , 2000 , 113 : 404 - 407 . Chin Med J 10.1016/S1001-8042(09)60015-4 R817.8 Supported by Department of Science and Technology of Xiamen City (Grant No. 3502Z20052017) . 2008-09-02 2008-12-20 2021-01-19 2008 Nuclear Science and Techniques 06 19