Comparable investigation in dopamine transporters with <sup>99m</sup>Tc-TRODAT-1 and <sup>131</sup>I-FP-CIT SPECT in Parkinson's disease patients

Congjin LIU; Xingdang LIU; Guangming ZHANG; Ding LI; Jian WANG; Liqin YANG; Yuping JIANG

doi:10.1016/S1001-8042(07)60052-9

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Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-29

- Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients
- Nuclear Science and Techniques Vol. 18, Issue 4, (2007)
- Affiliations：
  
  1.Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;
  2.Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
- Author bio：
  
  Corresponding author. E-mail: xingdliu@yahoo.com
  
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- Funds：
- DOI：10.1016/S1001-8042(07)60052-9 CLC： R445,R445.6
- Published：20 August 2007，
  
  Received：18 April 2007，
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Cite this article
Congjin LIU, Xingdang LIU, Guangming ZHANG, et al. Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients. [J]. Nuclear Science and Techniques 18(4):232-236(2007)
DOI：

Congjin LIU, Xingdang LIU, Guangming ZHANG, et al. Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients. [J]. Nuclear Science and Techniques 18(4):232-236(2007) DOI： 10.1016/S1001-8042(07)60052-9.

Comparable investigation in dopamine transporters with 99m Tc-TRODAT-1 and 131 I-FP-CIT SPECT in Parkinson's disease patients 1 first-author 1 corresp Corresponding author. E-mail: xingdliu@yahoo.com Corresponding author. E-mail: xingdliu@yahoo.com xingdliu@yahoo.com 1 1 2 2 2 Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that 99m Tc-TRODAT-1 SPECT and 131 I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The 99m Tc-TRODAT-1 image is more accurate and clearer compared with 131 I-FP-CIT. 99m Tc-TRODAT-1 SPECT 131 I-FP-CIT SPECT Parkinson's disease References LIU Xingdang , GUO Liping , JIANG Chengchuan , et al . Shanghai Med J (in Chinese) , 2002 , 25 ( 10 ): 607 - 609 . Shanghai Med J (in Chinese) LIU Xingdang , LIN Xiangtong , FANG Ping , et al . Chin J Nucl Med (in Chinese) , 2000 , 20 ( 6 ): 285 - 286 . Chin J Nucl Med (in Chinese) Hughes A J , Daniel S E , Kilford L , et al . Neurol Neurosurg Psychiatry , 1992 , 55 : 181 - 184 . Neurol Neurosurg Psychiatry Eshuis S A , Maquire R P , Leenders K L , et al . Eur J Nucl Med Mol Imaging , 2006 , 33 ( 2 ): 200 - 209 . Eur J Nucl Med Mol Imaging Booij J , Hemelaar J T G M , Speelman J D , et al . J Nucl Med , 1999 , 40 : 753 - 761 . J Nucl Med LIU Xingdang , LIN Xiangtong . Chin J Nucl Med (in Chinese) , 2003 , 23 ( 3 ): 160 - 162 . Chin J Nucl Med (in Chinese) LIU Xingdang , FANG Ping , CHEN Zhengping , et al . Chin J Nucl Med (in Chinese) , 2003 , 23 ( 1 ): 50 - 51 . Chin J Nucl Med (in Chinese) LIU Xingdang , LIN Xiangtong , KUANG Qinfang , et al . Asian J Nucl Med (in Chinese) , 2002 , 2 ( 3 ): 180 - 183 . Asian J Nucl Med (in Chinese) LIU Xingdang , LIN Xiangtong . Chin J Nucl Med (in Chinese) , 2000 , 20 ( 6 ): 263 - 265 . Chin J Nucl Med (in Chinese) LIU Xingdang , LIN Xiangtong , FANG Ping , et al . Chin J Nucl Med (in Chinese) , 2000 , 20 ( 3 ): 140 - 141 . Chin J Nucl Med (in Chinese) 10.1016/S1001-8042(07)60052-9 R445,R445.6 Supported by National "Tenth Five" Scientific Technique Research Plan Project (2001BA702B02) 2007-04-18 2007-08-20 2021-01-19 2007 Nuclear Science and Techniques 04 18

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Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients