Study on the preparation and biodistribution of ^99mTc-HMIBP

Study on the preparation and biodistribution of 99m Tc-HMIBP 1 2 first-author 2 1 corresp Corresponding author, e-mail: shineng914@yahoo.com.cn Corresponding author, e-mail: shineng914@yahoo.com.cn shineng914@yahoo.com.cn 2 1 2 2 2 2 2 School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China; School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, China; Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 99m Tc-HMIBP, a new bone-imaging agent, was prepared by the reduction of 99m Tc-pertechnetate in the presence of SnCl 2 •2H 2 O. The effects of the amounts of SnCl 2 •2H 2 O and HMIBP and the pH value on the labeling yield and radiochemical purity of 99m Tc-HMIBP were investigated. When the amounts of SnCl 2 •2H 2 O and HMIBP were more than 10 µg and 2.5 mg, respectively, the pH value was between 2 and 7, and the labeling reaction continued for 10 min, both labeling yield and radiochemical purity of 99m Tc-HMIBP were more than 90%. The biodistribution in rats and bone scan in rabbits were also studied. The results showed that the bone uptake is up to 7.94% ID/g at 30 min after injection of 99m Tc-HMIBP, bone-to-muscle and bone-to-blood uptake ratios were 20.89 and 16.89, respectively. The clear bone image was obtained at 120 min after injection of 99m Tc-HMIBP and clearance in soft tissue was visible. All of the above-mentioned results suggested that 99m Tc-HMIBP may be a potential bone-imaging agent. Bone-imaging agent 99m Tc-labeled HMIBP Biodistribution References Rudd T G , Allen D R , Hartnett D E . J Nucl Med , 1977 , 18 : 872 - 876 J Nucl Med Vasireddy S , Talwakar A , Miller H , et al . Clin. Rheumatol ., 2003 , 22 : 376 - 380 . Clin. Rheumatol Dawson N A . Expert. Opin. Pharmacother ., 2003 , 4 : 705 - 716 . Expert. Opin. Pharmacother Wang Hongyong , LUO Shineng , XIE Minhao , et al . Nucl Tech (in Chinese) , 2006 , 29 ( 6 ): 438 - 441 . Nucl Tech (in Chinese) Luo Shineng , WANG Hongyong , XIE Minhao , et al . Chin J Nucl Med ., 2005 , 25 ( 6 ): 341 - 343 . Chin J Nucl Med Widler L , Jaeggi K A , Glatt M , et al . J. Med. Chem ., 2002 , 45 : 3721 - 3738 J. Med. Chem Jaeggi K A , Widler L . 1990 , USP 4939130 . Liu Liqin , Yang Jianquan , Li Ye , et al . Journal of Beijing Normal University (Natural Science Edition) , 2003 , 39 ( 2 ): 230 - 234 Journal of Beijing Normal University (Natural Science Edition) 10.1016/S1001-8042(06)60053-5 R817 2006-08-10 2006-10-20 2021-01-19 2006 Nuclear Science and Techniques 05 17