Preparation and bio-distribution of ¹⁵³Sm-HEDTMP as a radiopharmaceutical for bone metastases

Preparation and bio-distribution of 153 Sm-HEDTMP as a radiopharmaceutical for bone metastases 1 first-author 1 2 2 1 1 1 2 Institute of Nuclear Physics and Chemistry, the China Academy of Engineering Physics, Mianyang 621900; Institute of Nuclear Physics and Chemistry, the China Academy of Engineering Physics, Mianyang 621900; Department of Nuclear Medicine of First University Hospital, West China Medicine Center, Sichuan University, Chengdu 610041 Department of Nuclear Medicine of First University Hospital, West China Medicine Center, Sichuan University, Chengdu 610041 HEDTMP (N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri(methylene phosphonic acid)) was labeled with 153 Sm. The formation condition, stability, rabbit bone imaging and mouse bio-distribution of 153 Sm -HEDTMP were investigated. The results showed that weak basic media and high ligand's concentration were favorable to form 153 Sm-HEDTMP, and neutral or weak basic media increase the stability of 153 Sm-HEDTMP. And the higher the concentration of HEDTMP was, the more stable the labeling complex was. Bio-distribution study indicated the uptake of 153 Sm-HEDTMP in skeleton was high ((25.68±1.22)ID%/g bone at 3 h post injection and (16.56±1.01)ID%/g bone at 48 h post injection), while the non-target tissue uptake and retention were relatively low, so 153 Sm-HEDTMP is a promising bone tumor therapeutic agent. Samarium-153 HEDTMP Bone tumor Bio-distribution References Luo S Z , Pu M F , Qiao J et al . Nucl Sci Tech , 1995 , 16 ( 3 ): 146 - 149 Nucl Sci Tech Serafini AN . Q J Nucl Med , 2001 , 45 ( 1 ): 91 - 99 Q J Nucl Med Berna L , Martin F , Cunill C et al . Rev Esp Med Nucl , 2001 , 20 ( 2 ): 130 - 131 Rev Esp Med Nucl Hchum Kim S , Chen D , Muggia F . Anticancer Res , 1988 , 8 : 681 - 684 Anticancer Res Mcewan AJB . Semin Radiat oncol , 2000 , 10 : 103 - 114 Semin Radiat oncol Crawford ED , Kozlowski JM , Debruyne FM et al . Urology , 1994 , 44 : 481 - 485 Urology Volkert W A , Deutsch E A . Advances in Metals in Medicine , Abrams M J eds, JAI Press , 1993 , 115 - 149 Advances in Metals in Medicine Volkert W A , Hoffman T J . Chem Rev , 1999 , 99 : 2269 - 2292 Chem Rev Luo S Z , Qiao J , Pu M F et al . Nucl Tech (in chinese) , 1996 , 19 : 236 - 240 Nucl Tech (in chinese) Jung A , Bisaz S , Fleisch H . Calcif Tissue Res , 1973 , 11 : 269 - 280 Calcif Tissue Res R979,R817,O628 Supported by CAEP Foundation (20020537) 2002-07-08 2004-04-01 2021-01-19 2004 Nuclear Science and Techniques 02 15