Labeling and stability study on ^99mTc-tissue plasminogen activator as thrombus and tumor imaging agent

Labeling and stability study on 99m Tc-tissue plasminogen activator as thrombus and tumor imaging agent 1 first-author 1 1 1 Jiangsu Institute of Nuclear Medicine, State Key Laboratory of Nuclear Medicine, Wuxi 214063 Jiangsu Institute of Nuclear Medicine, State Key Laboratory of Nuclear Medicine, Wuxi 214063 Tissue plasminogen activator (tPA), due to its stability in acidic solution, could be conveniently labeled with 99m Tc by using stannous chloride method. More than 90% of biochemical activity was remained after the process of labeling and separation. The stability of 99m Tc-tPA was studied at different time and different pH values, respectively. The study indicates that 99m Tc-tPA would be a potential imaging agent for thrombus and tumor. Tissue plasminogen activator 99m Tc Imaging agents Labeling Thrombus Tumors References Hnatowich D J , Virzi F , Doherty P W et al . Eur J Nucl Med , 1987 ; 13 : 467 — 473 Eur J Nucl Med Paulsma De Waal J H , De Boer A C , Cox P H et al . Nuc-compact , 1987 ; 18 : 284 — 286 Nuc-compact Karonen S L , Aronen H , Liewendahl K et al . J Nucl Med , 1988 ; 29 : 1194 — 1199 J Nucl Med Li Weiyi , Cao Guoxian , Zhang Rongjun . Nucl Tech (in Chinese) , 1994 ; 17 ( 7 ): 293 - 296 Nucl Tech (in Chinese) Deogny L , Weidenbach A , Hampton J W . Clin Chim Acta , 1975 ; 60 : 85 — 89 Clin Chim Acta Fry ETA , Mack D L , Monge J C et al . J Nucl Med , 1990 ; 30 : 187 — 191 J Nucl Med Uehara A , Isaka Y , Etani H et al . Nuclearmedizin (Germany) , 1987 ; 26 : 224 — 228 Nuclearmedizin (Germany) *The Project Supported by the Committee of Science and Technology, Jiangsu Province 1995-07-01 1996-02-01 2021-02-05 1996 Nuclear Science and Techniques 01 07