Determination of the degree of pulmonary artery hypertension by plasma atrial nateiuretic peptide levels and pulmonary perfusion imaging

Determination of the degree of pulmonary artery hypertension by plasma atrial nateiuretic peptide levels and pulmonary perfusion imaging 1 first-author 1 1 1 1 1 1 1 The 2nd Clinic College, China Medical University, Shenyang 110003 The 2nd Clinic College, China Medical University, Shenyang 110003 To evaluate the degree of pulmonary artery hypertension (PAH) and its significance, pulmonary perfusion tomographic imaging (PPTI) and radioimmunoassay of plasma atrial nateiuretic. peptide (ANP) levels were examined in different stages of rabbit PAH models, controlled with cardiac catheterization. When the PAH was mild. ANP levels were not significantly changed ( t =1, p > 0.05). The mean pulmonary artery pressures (mPAP) measured by catheterization had no significant change, but there was a significant increase of the ratio of dorsal/abdominal counts using pulmonary perfusion tomographic imaging (PPTI) ( t =2.5, p < 0.05). The ANP levels rose when PAH was moderate or severe, and the difference was significant compared with the control group ( t =4 and 6.5, p < 0.05). The other two methods also showed significant changes ( p < 0.01). There was positive correlation between the results of ANP/PPTI, ANP/catheterization, and PPTI/catheterizations ( p < 0.01). These results suggest that ANP levels can assess the degree of the PAH as a simple method, but it is not as sensitive as that of the PPTI in mild PAH. Atrial nateiuretic peptide Catheterization Pulmonary artery hyperten-sion Pulmonary perfusion imaging References Xue Q F , Xie J M , Hu C G et al . Chinese J Tuberculosis and Respiration , 1989 , 12 : 350 ~ 352 Chinese J Tuberculosis and Respiration Perrault T , Baribeau J , Gosselin S et al . Am J Physiol , 1997 , 273 : 289 - 295 Am J Physiol Adnot S , Andirvet P , Chabrier P E et al . Clin Invest , 1989 , 83 : 986 Clin Invest Cargill R I , Batt C S , Coutic W S et al . Thorax , 1994 , 49 : 1247 ~ 1249 Thorax Butkowsks J , Cantin M , Benest J et al . FEBS Lett , 1987 , 214 : 17 ~ 20 FEBS Lett Qin Q N , Zhao D G , Xia S Y et al . Chin Circul J , 1994 , 9 : 142 ~ 144 Chin Circul J Zhang C X , Li J M , Li Z J et al . Chin J Nucl Med , 1998 , 18 : 243 ~ 244 Chin J Nucl Med R543.2, R817.4, R446.61 Supported by a fund from Liaoning Province (No. 97802014) 2000-03-07 2000-11-01 2021-02-05 2000 Nuclear Science and Techniques 4 11