Killing effect of Chinese hamster V79 cells exposed to accelerated carbon ions and RBE determination

Killing effect of Chinese hamster V79 cells exposed to accelerated carbon ions and RBE determination 1 first-author 1 1 1 1 Insttute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000 Insttute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000 Survival curves of Chinese hamster V79 cells exposed to accelerated carbon ions with linear energy transfers of 125.5, 200 and 700 keV/ μ m were measured, respectively. Inactivation cross sections corresponding to the irradiation above were deduced from the V79 cell survival curves. They are 7.86±0.17, 10.44±1.11 and 32.32±3.58 μ m 2 in turn. With the surviving response of V79 cells to 60 Co γ -rays as a reference value, relative biological effectiveness at 10%, 20%, 50% and 80% survival levels were given for the accelerated carbon ions. The results showed that carbon ions with LET of 125.5 keV/ μ m had a higher value of RBE at all the four survival levels than the carbon ions with other LETs. It was prompted that the maximum value of RBE for the V79 cell surviving as the biological endpoint emerged at the LET below 200 keV/ μ m for carbon ions. Carbon ions V79 cells Inactivation cross section Relative biological effectiveness References Zhao D H , Liang C Q. Int Med Dev (in Chinese) , 1996 , 2 : 48 - 50 Int Med Dev (in Chinese) Stoll U , Schmidt A , Schneider E et al . Radiat Res , 1995 , 142 : 288 - 294 Radiat Res Kraft G. Nucl Sci Appl , 1987 , 3 : 1 - 28 Nucl Sci Appl Ziegler J , The transport of ions in matter , IBM-research 28-0 , 1992 , 1 - 23 The transport of ions in matter Xie H M , Wei Z Q , Li W J et al . Nucl Tech (in Chinese) , 1997 , 20 : 230 - 234 Nucl Tech (in Chinese) Li Q , Wei Z Q. Nucl Instr Meth , 1997 , 122B : 657 - 662 Nucl Instr Meth Scholz M , Kraft G. Adv Space Res , 1996 , 18 : 5 - 14 Adv Space Res Q691, R730 Jointly supported by the Western Hope Project of the Chinese Academy of Sciences (No.XB010612) and the Director Foundation of the Institute of Modern Physics, the Chinese Academy of Sciences (No.ZY010606) 2002-03-18 2002-11-01 2021-02-05 2002 Nuclear Science and Techniques 4 13