TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

Hui-Hui Xiao; Ling-Ling Liu; Wen-Yi Li; Bing-Bing Li; Xiang-Li Cui; Jie Li; Tao-Sheng Li; Zong-Tao Hu

doi:10.1007/s41365-023-01211-5

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TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

ACCELERATOR, RAY TECHNOLOGY AND APPLICATIONS | Updated：2023-06-07

- TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator
- Nuclear Science and Techniques Vol. 34, Issue 4, Article number: 53(2023)
- Affiliations：
  
  1.School of Basic Medical Sciences, Anhui Medical University, Hefei 230000, China
  2.Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, China
  3.Institute of Health and Medical Technology, Hefei Institute of Materials Science, Chinese Academy of Sciences, Hefei 230000, China
  4.University of Science and Technology of China, Hefei 230000, China
  5.Hefei Institute of Materials Science, Chinese Academy of Sciences, Hefei 230000, China
- Author bio：
  
  * huxuyan@163.com
- Funds：
- DOI：10.1007/s41365-023-01211-5
  CLC：
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Hui-Hui Xiao, Ling-Ling Liu, Wen-Yi Li, et al. TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator. [J]. Nuclear Science and Techniques 34(4):53(2023)
DOI：

Hui-Hui Xiao, Ling-Ling Liu, Wen-Yi Li, et al. TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator. [J]. Nuclear Science and Techniques 34(4):53(2023) DOI： 10.1007/s41365-023-01211-5.

摘要

Abstract

The application of a thermoluminescent detector (TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury (RILD) in mice, in order to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy (VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume (PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6J mice were randomly divided into control and 25 Gy radiation groups, and were examined daily for changes in body weight. they were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ±3% of the ,D,mean, value of the evaluation parameter in the TPS system. The mice in the 25 Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from –1.5% to 6%; construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.

关键词

Keywords

Thermoluminescent detectorRadiation-induced liver injuryLinear acceleratorVolumetric rotational intensity-modulated radiotherapy

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