This article presents a brief overview of the development of high-resolution SPECT for small-animal imaging. A pinhole collimator has been used for high-resolution animal SPECT to provide better spatial resolution and detection efficiency in comparison with a parallel-hole collimator. The theory of imaging characteristics of the pinhole collimator is presented and the designs of the pinhole aperture are discussed. The detector technologies used for the development of small-animal SPECT and the recent advances are presented. The evolving trend of small-animal SPECT is toward a multi-pinhole and a multi-detector system to obtain a high resolution and also a high detection efficiency.
关键词
Keywords
Small-animal SPECTMolecular imagingPinhole collimationGamma camera
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Department of Engineering Physics, Tsinghua University
Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education
Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics
Key Laboratory of Nuclear Technology Application and Radiation Protection in Astronautics (Nanjing University of Aeronautics and Astronautics), Ministry of Industry and Information Technology, Nanjing University of Aeronautics and Astronautics
Assistant Professor of Medical Physics, School of Medicine, Rafsanjan University of Medical Sciences