Comparable investigation in dopamine transporters with <sup>99m</sup>Tc-TRODAT-1 and <sup>131</sup>I-FP-CIT SPECT in Parkinson's disease patients

Congjin LIU; Xingdang LIU; Guangming ZHANG; Ding LI; Jian WANG; Liqin YANG; Yuping JIANG

doi:10.1016/S1001-8042(07)60052-9

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Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-29

- Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients
- Nuclear Science and Techniques Vol. 18, Issue 4, (2007)
- Affiliations：
  
  1.Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;
  2.Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
- Author bio：
  
  Corresponding author. E-mail: xingdliu@yahoo.com
- Funds：
- DOI：10.1016/S1001-8042(07)60052-9
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Congjin LIU, Xingdang LIU, Guangming ZHANG, et al. Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients. [J]. Nuclear Science and Techniques 18(4):232-236(2007)
DOI：

Congjin LIU, Xingdang LIU, Guangming ZHANG, et al. Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients. [J]. Nuclear Science and Techniques 18(4):232-236(2007) DOI： 10.1016/S1001-8042(07)60052-9.

摘要

Abstract

Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that,99m,Tc-TRODAT-1 SPECT and ,131,I-FP-CIT SPECT may serve as sensitive and objective ,in vivo, markers to reflect the severity of PD. The ,99m,Tc-TRODAT-1 image is more accurate and clearer compared with ,131,I-FP-CIT.

关键词

Keywords

99mTc-TRODAT-1 SPECT131I-FP-CIT SPECTParkinson's disease

references

LIU Xingdang, GUO Liping, JIANG Chengchuan, et al. Shanghai Med J (in Chinese), 2002, 25(10): 607-609.

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LIU Xingdang, FANG Ping, CHEN Zhengping, et al. Chin J Nucl Med (in Chinese), 2003, 23(1): 50-51.

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LIU Xingdang, LIN Xiangtong, FANG Ping, et al. Chin J Nucl Med (in Chinese), 2000, 20(3): 140-141.

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Related Institution

Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine

Jiangsu Institute of Nuclear Medicine, Key Laboratory of Nuclear Medicine, Ministry of Health

PET Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Nuclear Medicine Department, Nanjing No.1 Hospital Affiliated to Nanjing Medical University

Nuclear Medicine Department, Second Hospital Affiliated to Suzhou University, Nuclear Medicine Research Institute of Suzhou University

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Comparable investigation in dopamine transporters with 99mTc-TRODAT-1 and 131I-FP-CIT SPECT in Parkinson's disease patients

DOI：10.1016/S1001-8042(07)60052-9

摘要

Abstract

关键词

Keywords

references

Comparable investigation in dopamine transporters with ^99mTc-TRODAT-1 and ¹³¹I-FP-CIT SPECT in Parkinson's disease patients