Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice

Yang LIU; Luwei ZHANG; Hong ZHANG; Zhenhua WU; Zhenhua Wang; Yibo WANG; Hongyan LI; Xiaofei MA; Yi XIE

doi:10.13538/j.1001-8042/nst.2013.06.002

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Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice

NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-20

- Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice
- Nuclear Science and Techniques Vol. 24, Issue 6, Article number: 060303(2013)
- Affiliations：
  
  1.Department of Heavy Ion Radiation Medicine, Institute of Modern physics, Chinese Academy of Sciences, Lanzhou 730000, China
  2.Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China
  3.Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China
  4.College of Life Science and chemistry, Tianshui Normal University, Tianshui 741000, China
- Author bio：
  
  Corresponding author. E-mail address: zhangh@ impcas. ac.cn
- Funds：
- DOI：10.13538/j.1001-8042/nst.2013.06.002
  CLC：
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Yang LIU, Luwei ZHANG, Hong ZHANG, et al. Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice. [J]. Nuclear Science and Techniques 24(6):060303(2013)
DOI：

Yang LIU, Luwei ZHANG, Hong ZHANG, et al. Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice. [J]. Nuclear Science and Techniques 24(6):060303(2013) DOI： 10.13538/j.1001-8042/nst.2013.06.002.

摘要

Abstract

This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice, and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity. The results demonstrated that significant reductions in spermatozoa, primary spermatocytes and spermatogonia, and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over 0.4 Gy irradiation. Collectively, the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation (0.2 Gy) in mouse testis compared to the control group. However, testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity, which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells.

关键词

Keywords

Stimulated microgravityHigh-LET irradiationCarbon ionMouse testis

references

Kierfer J, Proess H D. Mutat Res, 1999, 430: 299-305.

Norsk, P. Curr Pharm Biotechnol, 2005, 6: 325-330.

Delp M D. J Appl Physiol, 1999, 86: 1178-1184.

Smith S M, Wastney M E, O'Brien K O, et al. FEBS Lett, 2000, 477: 135-140.

Fitts R H, Riley D R, Widrick J J. J Appl Physiol, 2000, 89: 823-839.

Macho L, Koska J, Ksinantova L, et al. Adv Space Res, 2003, 31: 1605-1610.

Sonnenfeld G. Curr Pharm Biotechnol, 2005, 6: 343-349.

Tedeschi G, Pagliato L, Negroni M, et al. Cell Boil Int, 2011, 35: 249-258.

Kamiya H, Sasaki S, Ikeuchi T, et al. J Androl, 2003, 24: 885-890.

Motabagani M A. Chin J Physiol, 2007, 50: 199-209.

Masini M A, Prato P, Scarabeli L, et al. Adv Space Res, 2011, 47: 575-581.

Hadley J A, Hall J C, O'Brien A, et al. J Appl Physiol, 1992, 72: 748-759.

Blakely E A, Chang P Y. Adv Space Res, 2007, 40: 461-469.

Ritter M A, Cleaver J E, Tobias C A. Nature, 1999, 266: 653-655.

Sekine E, Okada M, Matsufuji N, et al. Mutat Res, 2008, 652: 95-101.

Pathak P, Dey S K, Sarma A, et al. Mutat Res, 2007, 632: 58-68.

Zhao W P, Zhang H, Wang Y L, et al. J Radiat Res Radiat Process, 2008, 26: 343-347.

Liu Y, Zhang H, Zhang L, et al. Pharmazie, 2009, 64: 461-469.

Liu Y, Long J, Zhang L W, et al. Adv Space Res, 2011, 47: 55-59.

Zhang H, Zhao W P, Wan Y L, et al. Mutat Res, 2008, 653: 109-112.

Zhang H, Zheng R L, Wang R Y, et al. Mutat Res, 1998, 398: 27-31.

Chen J, Ma J, Ding Z P, et al. Chin J Space Sci, 1993, 13:159-162.

Rao D V, Narra V R, Howell R W, et al. Radiat Res, 1991, 125: 89-97.

D'Souza U J. Asian J Androl, 2003, 5: 217-220.

Silaev A A, Kasparov A, Korolev V V, et al. Morphol Pathomorphol, 1977, 46: 27-32.

Forsman A D. Adv Space Res, 2012, 49: 807-811.

Russell W L, Bangham J W, Russell L B. Genetics, 1998, 148: 1567-1578.

Liu G, Gong P, Bernstein L R, et al. Crit Rev Toxicol, 2007, 37: 587-605.

Zhang L W, Liu Y, Zhang H. Nucl Phys Rev, 2011, 28: 337-342.

Zhou L X, Cui S, Zhong J, et al. Adv Space Res, 2010, 46: 1237-1244.

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PLAC, Key Laboratory of Quark & Lepton Physics (MOE), Department of Physics Science and Technology, Central China Normal University

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