A high-resolution small animal SPECT system developed at Tsinghua

Tiantian DAI; Tianyu MA; Hui LIU; Junjian CUI; Qingyang WEI; Yaqiang LIU; Shi WANG

doi:10.13538/j.1001-8042/nst.22.344-348

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A high-resolution small animal SPECT system developed at Tsinghua

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-29

- A high-resolution small animal SPECT system developed at Tsinghua
- Nuclear Science and Techniques Vol. 22, Issue 6, (2011)
- Affiliations：
  
  1.Key Laboratory of Particle & Radiation Imaging, Ministry of Education; Department of Engineering Physics, Tsinghua University, Beijing 10084, China
- Author bio：
  
  Corresponding author. E-mail address: maty@tsinghua.edu.cn
- Funds：
- DOI：10.13538/j.1001-8042/nst.22.344-348
  CLC：
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Tiantian DAI, Tianyu MA, Hui LIU, et al. A high-resolution small animal SPECT system developed at Tsinghua. [J]. Nuclear Science and Techniques 22(6):344-348(2011)
DOI：

Tiantian DAI, Tianyu MA, Hui LIU, et al. A high-resolution small animal SPECT system developed at Tsinghua. [J]. Nuclear Science and Techniques 22(6):344-348(2011) DOI： 10.13538/j.1001-8042/nst.22.344-348.

摘要

Abstract

An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better. This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost. It was developed from a single-head clinical SPECT scanner, with a seven-pinhole collimator and a four-degree-of- freedom motion control stage. Several key techniques were developed, including high-resolution image reconstruction algorithm, high accuracy geometrical calibration method, and optimized system matrix derivation scheme. The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function. Experiments of point source and ultra micro hot rod phantom were conducted. With a spatial resolution of 0.5–0.6 mm, this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.

关键词

Keywords

SPECTMulti-pinhole collimatorHigh resolutionSystem matrixImage reconstruction

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