Biodistribution study of [<sup>61</sup>Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

Amir Reza JALILIAN; Saeed SHANESAZZADEH; Pejaman ROWSHANFARZAD; Fatemeh BOLOURINOVIN; Abbas MAJDABADI

doi:10.1016/S1001-8042(08)60043-3

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Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE | Updated：2021-01-29

- Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer
- Nuclear Science and Techniques Vol. 19, Issue 3, (2008)
- Affiliations：
  
  1.Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran;
  2.Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
- Author bio：
  
  Corresponding author. E-mail: ajalilian@nrcam.org
  
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- Funds：
- DOI：10.1016/S1001-8042(08)60043-3 CLC： R817.4,O621.3⁺5
- Published：20 June 2008，
  
  Received：24 January 2008，
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Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, et al. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer. [J]. Nuclear Science and Techniques 19(3):159-164(2008)
DOI：

Amir Reza JALILIAN, Saeed SHANESAZZADEH, Pejaman ROWSHANFARZAD, et al. Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer. [J]. Nuclear Science and Techniques 19(3):159-164(2008) DOI： 10.1016/S1001-8042(08)60043-3.

Biodistribution study of [ 61 Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer 1 corresp first-author Corresponding author. E-mail: ajalilian@nrcam.org Corresponding author. E-mail: ajalilian@nrcam.org ajalilian@nrcam.org 2 1 1 1 Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran; Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran; Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran [ 61 Cu]-labeled pyruvaldehyde-bis(N-4-methylthiosemicarbazone) ( 61 Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the nat Zn(p,x) 61 Cu nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150 μA irradiation for 76 min, about 6.006 Ci of 61 Cu 2+ was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. 61 Cu-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [ 61 Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors. Copper-61 PTSM Biodistribution Radiolabeling References Jalilian AR , Seyfi P , Afarideh H , et al . Int. J Appl Radiat Isot . 2000 , 5 : 545 - 555 . Int. J Appl Radiat Isot Jalilian AR , Afarideh H , Shafiee A , et al . J Pharm Pharmaceut. Sci . 2000 ; 23 : 114 - 124 . J Pharm Pharmaceut. 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Biodistribution study of [61Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

Biodistribution study of [⁶¹Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer