Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast

Nondestructive X-ray imaging of inner structure of soft tissues in phase contrast 1 first-author 1 1 2 2 2 Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800; Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, Shanghai 201800; Institute of High Energy Physics, the Chinese Academy of Sciences, Beijing 100033 Institute of High Energy Physics, the Chinese Academy of Sciences, Beijing 100033 An experimental study on nondestructive X-ray imaging of inner structure of soft tissues in phase contrast has been conducted with Beijing Synchrotron Radiation Facility (BSRF). Modification to the beamline setup was made to enlarge the X-ray beam section and consequently larger samples could be imaged. In-line setup was employed for experiments. Results on a series of samples were given and soft-tissue details of less than 50μm inside a fresh goldfish were obtained. Diagnosis of tumor in its early stage was also investigated taking SD rats as the model. Tumor at the size of ~100μm was observed. Potential of this technique in clinic diagnosis was discussed. Nondestructive imaging Phase contrast Synchrotron radiation Clinic diagnosis References Fitzgerald R . Physics Today , 2000 , 53 ( 7 ): 23 Physics Today Wilkins S W , Gureyev T E , Gao D . Nature , 1996 , 384 ( 6607 ): 335 - 338 Nature Arfelli F , Tromba G , Bonvicini V et al . Elettra Hightlights , www.elettra.trieste.it , 1997 Elettra Hightlights Hwua Y , Tsaia W-L , Hsieha H-H et al . Nucl Instr Methods Phys Res A , 2001 , 467-468 : 1294 - 1300 Nucl Instr Methods Phys Res A Stevenson A W , Gureyev T E , Paganin D et al . Nucl Instr Methods Phys Res B , 2003 , 199 : 427 - 435 Nucl Instr Methods Phys Res B Snigirev A , Snigireva I , Kohn V et al . Rev Sci Instrum , 1995 , 66 : 5486 - 5492 Rev Sci Instrum Max Born , Emil Wolf . Principles of optics ( 5 th ed.), Pergamon Press , 1975 Principles of optics Xiao T Q , Xu H J , Zhang Y J et al . J Mod Opt , 1998 , 45 ( 2 ): 343 - 353 J Mod Opt Pogany A , Gao D , Wilkins W W . Rev Sci Instrum , 1997 , 68 ( 7 ): 2774 - 2782 Rev Sci Instrum Snigirev A , Kohn V , Snigireva A et al . Nature , 1996 , 384 : 49 Nature Webb S (ed). The Physics of Medical Imaging, Bristol: Hilger , 1978 The Physics of Medical Imaging, Bristol: Hilger Bushuev V A , Ingal V N , Beliaevskaya E A . Crystallography Reports , 1996 , 41 ( 5 ): 766 - 774 Crystallography Reports Beliaevskaya EA , Ingal VN . Il Nuovo Cimento , 1997 , 19D ( 2-4 ): 553 - 560 Il Nuovo Cimento Ingal V N , Beliaevskaya E A , Brianskaya A P et al . Phys Med Biol , 1998 , 43 ( 9 ): 2555 - 2567 Phys Med Biol R445.4,O434.1 Supported by National Natural Science Foundation of China (No.10275087) , Shanghai Foundation on Development of Science and Technology (No.022261023) and Shanghai Foundation for Natural Science (No.02ZF14116) 2002-12-13 2003-11-01 2021-01-19 2003 Nuclear Science and Techniques 04 14