THE METABOLISM OF TITANIUM AND OTHER ELEMENTS IN WISTER RATS

THE METABOLISM OF TITANIUM AND OTHER ELEMENTS IN WISTER RATS 1 first-author 2 2 1 1 2 2 1 1 Institute of High Energy Physics, Academia Sinica, Beijing 100080, China Institute of High Energy Physics, Academia Sinica, Beijing 100080, China Beijing Institute of Labour Hygiene and Occupation Diseases, Beijing 100020, China Beijing Institute of Labour Hygiene and Occupation Diseases, Beijing 100020, China The concentrations of Ti and Ca, P, K, Fe, Cu and Zn in blood samples were determined by PIXE after a single intravenous and a single oral dosing with titanium- ascorbate (Ti- Vc) in Wister rats. Following the intravenous injection with 50 mg Ti- Vc/kg body weight, the absorption, distribution and clearance in blood could be described by an exponential equation of three terms. After gavaged with 500 mg Ti- Vc/kg body weight, at 1.5 h the content of Ti reached the highest level. The concentration of Ca was increasing with the absorption, distribution and clearance of Ti in blood. The contents of Fe and K were decreasing. And the contents of Cu and Zn were significantly fluctuating. The effect of Ti on animal growth could be explained by the fact that Ti- Vc supplementation could promote the absorption of Ca. PIXE Titanium- ascorbate Pharmacokinetics Dosing Major and trace elements REFERENCES I. Pais , Proc. 4th international trace element symposium , Budapest , 1990 , p. 191 . I. Pais , Proc. 4th international trace element symposium , Budapest , 1990 , p. 289 . G. Kazantzis , Environmental Health Prespectrives , 40 ( 1981 ), 143 . Environmental Health Prespectrives L. Friberg et al ., Handbook on the toxicology of metals , Vol. II , Elsevier , Amsterdam , 1986 . Handbook on the toxicology of metals M. Glbaldi and D. Perrier , Pharmacokinetics , Marcel Dekker Inc ., New York , 1975 , p. 280 , Pharmacokinetics M. Glbaldi and D. Perrier , Pharmacokinetics , Marcel Dekker Inc ., New York , 1975 , p. 89 Pharmacokinetics Wang Min , "The toxicokinetics of titanium- ascorbate in rats" , Thesis , Beijing Institute of Labor Hygiene and Occupation Diseases , 1990 . "The toxicokinetics of titanium- ascorbate in rats" J.L. Li , Proc. Division of Beijing Association Chinese Academy of Preventive Medicine (in Chinese) , 1990 , p. 80 . J.L. Li , Proc. Division of Beijing Association Chinese Academy of Preventive Medicine (in Chinese) , 1990 , p. 85 . The Project Supported by National Natural Science Foundation of China 1991-08-01 2021-02-05 1991 Nuclear Science and Techniques 3 2