Pharmacokinetics local model and its application in nuclear medicine

Pharmacokinetics local model and its application in nuclear medicine 1 first-author 1 1 Jiangsu Institute of Nuclear Medicine, Wuxi 214063 Jiangsu Institute of Nuclear Medicine, Wuxi 214063 The Pharmacokinetics local model for studying kinetic action of pharmaceuticals in the specific part of the body is established on the basis of the compartment model. A series of formulae is deduced, and with them the pharmacokinetic equation and several important parameters can be obtained. The local model successfully expanded the area of pharmacokinetics from the compartment model, which is mainly dealing with kinetic action of pharmaceuticals in blood, to the local model, which can study kinetic action of pharmaceuticals in any organ, tissue or fluid. Pharmacokinetics Mathematical model Local model Computer program. References Gibaldi M , Perrier D . Pharmacokinetics . Second Edition, Revised and Expanded . New York : Marcel Dekker , 1982 Pharmacokinetics Liu Chang-Xiao , Liu Ding-Yuan . Introduction of pharmacokinetics (in Chinese) . Beijing : China Academic Publishing House , 1984 Introduction of pharmacokinetics (in Chinese) Shao He-Seng , Tian Jia-He , Kuang Qin-Fang et al . Chinese J Nucl Med , 1988 ; 8 : 209 Chinese J Nucl Med *The Project Supported by Natural Science Foundation of Jiangsu Province, China 1996-03-05 1996-08-01 2021-02-05 1996 Nuclear Science and Techniques 3 7