Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice

Dao-Yan Wei; Ao-Xing Jin; Guo Huang; Si-Ying Wang; Xiang-Sheng Zuo

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Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice

Updated：2021-02-05

- Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice
- Nuclear Science and Techniques Vol. 7, Issue 3, (1996)
- Affiliations：
  
  1.Department of Nuclear Medicine, Anhui Medical University, Hefei 230032
- Author bio：
  
  The First Affliated Hospital of Anhui Medical University, Hefei 230022
  
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- Funds：
- DOI： CLC：
- Published：01 August 1996，
  
  Received：20 December 1995，
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Cite this article
Dao-Yan Wei, Ao-Xing Jin, Guo Huang, et al. Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice. [J]. Nuclear Science and Techniques 7(3):180-182(1996)
DOI：

Dao-Yan Wei, Ao-Xing Jin, Guo Huang, et al. Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice. [J]. Nuclear Science and Techniques 7(3):180-182(1996) DOI：

Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice 1 first-author 1 1 1 1 corresp The First Affliated Hospital of Anhui Medical University, Hefei 230022 The First Affliated Hospital of Anhui Medical University, Hefei 230022 Department of Nuclear Medicine, Anhui Medical University, Hefei 230032 Department of Nuclear Medicine, Anhui Medical University, Hefei 230032 By using the models of tumor blood-borne metastasis and spontaneous one, the antitumor metastasis effect of 75 mGy X-ray whole body irradiation on tumor bearing mice is investigated. The results demonstrate that irradiation could significantly inhibit B16 melanoma blood borne pulmonary metastases ( P < 0.05) and Lewis lung carcinoma (LLC) spontaneous pulmonary metastases ( P < 0.01). The immunofunction test of B16 melanoma bearing mice shows that the NK ( P < 0.05) and LAK ( P < 0.001) cytotoxicities, and responsibility of splenocytes to 1L-2 ( P < 0.005) for the irradiated group are increased greatly compared with those of control group. These results suggest that the enhancement of immunofunctions is induced by low dose radiation to raise antitumor metastasis effects. Low dose radiation Metastasis of neoplasm Mice X-rays References Wei Dao-Yan , Jin Ao-Xing , Huang Guo et al . Acta Universitatis Medicinalis Anhui (in Chinese) , 1995 , 30 ( 5 ): 7 Acta Universitatis Medicinalis Anhui (in Chinese) Ding Gui-Leng , Xi Hong-Li , Deng Yulan et al . Shanghai Journal of Immunology (in Chinese) , 1988 ; 8 ( 1 ): 64 Shanghai Journal of Immunology (in Chinese) Korzeniewski C , Callewaert DM , Journal Immunological Methods , 1983 ; 63 : 313 Journal Immunological Methods Holder D L . Radiology , 1965 ; 84 : 83 Radiology Chaffey J T , Rosenthal D S , Molony W C et al . Int J Radiat Oncol Biol Phys , 1976 ; 1 : 399 Int J Radiat Oncol Biol Phys Luckey T D . Health Phys , 1982 ; 43 : 771 Health Phys Zhai Shao-Hua , Ling Xiou-Jian , Pan Tian-Mei et al . Chinese Journal of Radiological Medicine and Protection (in Chinese) , 1982 ; 2 ( 2 ): 48 Chinese Journal of Radiological Medicine and Protection (in Chinese) Anderson R E , Tokuda S , Williams W L et al . Br J Cancer , 1986 ; 54 : 505 Br J Cancer Yin Hong-Shu , Yu Kai-Jun , Wang Xian-Li et al . Journal of Norman Bethune University of Medical Sciences , 1995 ; 21 ( 1 ): 33 Journal of Norman Bethune University of Medical Sciences Zhang You-Hui . Modern oncology (foundmental section) . Beijing : Beijing Medical University and Peking Union Medical University Press , 1993 ; 212 Modern oncology (foundmental section) Barlozzari T , Leonhardt J , Wiltrout R H et al . J Imm , 1985 ; 134 ( 4 ): 2783 J Imm *The Project Supported by National Natural Science Foundation of China 1995-12-20 1996-08-01 2021-02-05 1996 Nuclear Science and Techniques 3 7

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