Effect of some factors on direct ^99mTc monoclonal antibody labelling efficiency

Effect of some factors on direct 99m Tc monoclonal antibody labelling efficiency 1 first-author 1 1 1 2 2 2 Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 Shanghai No.6 People's Hospital, Shanghai 200233 Shanghai No.6 People's Hospital, Shanghai 200233 This study is focused in the influence of some experimental factors on direct 99m Tc monoclonal antibody labelling method. The factors include weak ligands, reducing agent content and reduction time used in labelling. Biodistribution and scintigraphic imaging of animals are also performed. Finally, optimal parameters are supposed. Technetium-99m labelling Monoclonal antibody (MoAb) Ligands Biodistribution References Schwarz A , Steinstrasser A . J Nucl Med , 1987 ; 28 : 721 J Nucl Med Spencer R P , ed. New procedures in nuclear medicine . Florida : CRC Press, Inc. , 1989 ; 148,186 New procedures in nuclear medicine Mather S J , Ellisom D . J Nucl Med , 1990 ; 31 : 692 J Nucl Med Thakur M L , De Fulvio J , Richard M D et al . Nucl Med Biol , 1991 ; 18 : 227 Nucl Med Biol Oster Z H , Son P , Rhodes B A et al . Nucl Med Biol , 1993 ; 20 : 225 Nucl Med Biol The Project Supported by International Atomic Energy Agency and by Natural Science Funds of Shanghai 1996-04-20 1996-11-01 2021-02-05 1996 Nuclear Science and Techniques 4 7