Study on animals' femur blood flow alteration under inadequate decompression with ¹³³Xe isotope washout method

Study on animals' femur blood flow alteration under inadequate decompression with 133 Xe isotope washout method 1 first-author 1 2 2 2 2 2 Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 Naval Medical Research Institute, Shanghai 200433 Naval Medical Research Institute, Shanghai 200433 Animals' regional femur blood ( F ) alteration was studied under an inadequate decompression by using the inhaled isotope 133 Xe washout method. Results showed that the average F on left and right side of minipigs' femur decreased from 15.4±1.8 and 16.9±2.0ml/ (100g•min) (before exposure) to 10±1.8 and 11.1±1.6ml/ (100mg•min) (after expposure for 1.5 h under the pressure of 0.5 MPa and then decompression to normal with the rate of 0.03〜0.04 MPa/min) , respectively; the blood flow of hematopoietic marrow tissues ( f 1 ) on both sides also decreased from 19.3±2.0 and 22.1±1.9ml/ (100mg•min) to 13.9±1.4 and 13.8±1.0ml/(100mg·min) . The exact same alteration also happened in the experiment on New Zealand rabbits. It indicates that inadequate decompression in hyperbaric exposure can give rise to decrease animals' bone blood flow and insufficient bone blood supply serves as one of the reasons for causing decompressive osteonecrosis. Bone blood flow 133 Xe washout method Decompressive osteonecrosis Minipigs New Zealand rabbits References Bove A , Famiano F , Levin L et al . Undersea Biomed Res , 1977 , 4 ( 2 ): 169 Undersea Biomed Res Lahtincn T , Alhava EM , Karjalainen P et al . J Nucl Med , 1981 , 22 : 966 J Nucl Med Lahtincn R , Karjalainen P , Alhava EM et al . J Nucl Med , 1982 , 23 : 218 J Nucl Med Pooley J , Walder D N . Studies of bone marrow blood flow in rabbits during simulated dives . EUBS 5th Ann Science Meeting , 1980 , p189 Studies of bone marrow blood flow in rabbits during simulated dives Hills B , Strales R . Aerospace Med , 1972 , 43 ( 7 ): 724 Aerospace Med Walder D N. Holloway I . Role of oxygen in dysbaric osteonecroses . 9th International Symposium on underwater and hyperbaric Physiology . Undersea Hyperbaric Medical , Bethesda MD , 1987 , p613 Role of oxygen in dysbaric osteonecroses 1997-11-17 1998-05-01 2021-02-05 1998 Nuclear Science and Techniques 2 9