¹⁸⁸Re-labeled McAb 3H11 used as preventive for the peritoneal micrometasis of gastric cancer

188 Re-labeled McAb 3H11 used as preventive for the peritoneal micrometasis of gastric cancer 1 first-author 1 1 1 1 1 1 1 School of Clinical Oncology, Beijing Medical University and Beijing Cancer Hospital Beijing 100036 School of Clinical Oncology, Beijing Medical University and Beijing Cancer Hospital Beijing 100036 In advancing gastric cancer, especially when the serous is invaded, the plantation of cancer cells in peritoneal is common and it affects patients' survival time severely. Based on successfully labeled McAb (monoclonal antibody) 3H11 with 188 Re, we investigated the effect of RIT (Radioimmuno-Therapy) with 188 Re-3Hll on preventing the peritoneal micrometastasis of gastric cancer cells in nude mice to increase the survival time. After 1×10 6 BGC-823 gastric cancer cells were injected into the peritoneal cavity of each mouse, 45BABL/C nude mice were divided into 9 groups. Each group received different doses of 188 Re-3Hll or 188 Re-IgG, or saline I.P.16 hours postoperation. The injected volume of each mouse was 1.0mL. The results showed that the survival time depended on the injected doses during 0 to 37 MBq. The survival time was 170±25.3d after 37 MBq 188 Re-3H11 were treated. It was over 5 times more than that for the saline group and about 3 times more than that for 37 MBq 188 -Re IgG group ( p < 0.05). The mice hemogram were reduced to lowest 14 days after injection, but they recovered after 28 d. Conclusion: with proper injection doses,early postoperative 188 Re-3H11 I.P. is effective and safe for the prevention of intra-peritoneally injected gastric cancer cells from surviving,growing and disseminating in nude mice. Gastric caner Micrometasis 188 Re-labeled monoclonal antibody References Lu D P. Mou A P , Han Y et al . J Beijing Med University , 1996 . 28 : 154 ~ 155 J Beijing Med University Griffiths G L , Goldenberg D M , knapp F F et al . Cancer Res , 1991 . 51 : 4594 ~ 4602 Cancer Res Yang Z , Zhang M Y. Lin B H et al . J Radioanal Nucl Chem , 1996 , 206 : 59 ~ 67 J Radioanal Nucl Chem Yang Z , Mou A P , Lin B H et al . Eur J Nucl Med , 1998 . 25 : 1181(OT-12) . Eur J Nucl Med 1999-09-15 1999-11-01 2021-02-05 1999 Nuclear Science and Techniques 4 10