Application of pharmacokinetics local model to evaluate renal function

Application of pharmacokinetics local model to evaluate renal function 1 first-author 1 1 Jianyuan Hospital, State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 Jianyuan Hospital, State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 Abstract The pharmacokinetics local model was used to evaluate renal function. Some typical kinds of renal function cases, normal or disorder, were selected to be imaged with SPECT and those data measured were treated by the pharmacokinetics local model computer program (PLM). The results indicated that parameters, including peak value, peak time, inflexion time, half-excretion time, and kinetic equation played and important role in judging renal function. The fact confirms that local model is very useful in evaluating renal function. Renal function Pharmacokinetics Local model SPECT References Gibali M , Perrier D . Pharmacokinetics. 2 Edition, Revised and expanded . New York : Darcel Dekker , 1982 Pharmacokinetics. 2 Edition, Revised and expanded LIU Changxiao , LIU Dingyuan . Introduction of pharmacokinetics (in Chinese) . Beijing : China Academic Publishing House , 1984 Introduction of pharmacokinetics (in Chinese) CAO Guoxian , LI Weiyi , YU Huixin . Nucl Sci Tech , 1996 , 7 : 170 ~ 172 Nucl Sci Tech XU Xingcuang , WAN Weixing , WU Pengxi . Chi J Nucl Med , 1993 , 13 : 87 ~ 88 Chi J Nucl Med The Project Supported by Natural Foundation of Jiangsu Province China 1998-08-24 1999-02-01 2021-02-05 1999 Nuclear Science and Techniques 1 10